@article{31781535409246c3967e3bd70fdfe93a,
title = "Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy",
abstract = "Objective: Determine whether blanket temperatures during therapeutic hypothermia (TH) are associated with 18–22 month outcomes for infants with hypoxic ischemic encephalopathy (HIE). Study design: Retrospective cohort study of 181 infants with HIE who received TH in two randomized trials within the Neonatal Research Network. We defined summative blanket temperature constructs and evaluated for association with a primary composite outcome of death or moderate/ severe disability at 18–22 months. Results: Each 0.5 °C above 33.5 °C in the mean of the highest quartile blanket temperature was associated with a 52% increase in the adjusted odds of death/ disability (aOR 1.52, 95% CI 1.09–2.11). Having >8 consecutive blanket temperatures above 33.5 °C rendered an aOR of death/disability of 5.04 in the first 24 h (95% CI 1.54–16.6) and 6.92 in the first 48 h (95% CI 2.20–21.8) of TH. Conclusions: Higher blanket temperature during TH may be an early, clinically useful biomarker of HIE outcome.",
author = "{Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network} and John Flibotte and Laptook, {Abbot R.} and Seetha Shankaran and McDonald, {Scott A.} and Baserga, {Mariana C.} and Bell, {Edward F.} and Cotten, {C. Michael} and Abhik Das and DeMauro, {Sara B.} and DuPont, {Tara L.} and Eichenwald, {Eric C.} and Roy Heyne and Jensen, {Erik A.} and {Van Meurs}, {Krisa P.} and Kevin Dysart and {Van Meurs}, {Krisa P.}",
note = "Funding Information: This work was supported and funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the Neonatal Research Network (NRN). Participating NRN sites collected data and transmitted it to RTI International, the data coordinating center (DCC) for the network, which stored, managed and analyzed the data for this study. On behalf of the NRN, RTI International had full access to all of the data in the study, and with the NRN Center Principal Investigators, takes responsibility for the integrity of the data and accuracy of the data analysis. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in the original trials informing this study. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2022",
month = mar,
doi = "10.1038/s41372-021-01302-4",
language = "English (US)",
volume = "42",
pages = "348--353",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "3",
}