Abstract
Functionality, one of the key attributes of atom transfer radical polymerization (ATRP), was utilized for the synthesis of well-controlled polymers functionalized with biotin, pyrene, and peptides. Hydroxy- functionalized poly(oligo(ethylene oxide) monomethyl ether methacrylate) (HO-POEOMA) was prepared by AGET ATRP of OEOMA initiated by 2-hydroxyethyl 2-bromoisobutyrate in water or in inverse miniemulsion of water/cyclohexane at ambient temperature. HO-POEOMA was then further functionalized with biotin, pyrene, and GRGDS peptide. In addition, ATRP and click chemistry offered an efficient route for the synthesis of telechelic di-biotin polymers. These general methods can be applied to the formation of different functional materials conjugated with proteins, dyes, nucleic acids, and drugs.
Original language | English (US) |
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Pages (from-to) | 2179-2193 |
Number of pages | 15 |
Journal | Macromolecular Chemistry and Physics |
Volume | 209 |
Issue number | 21 |
DOIs | |
State | Published - Nov 6 2008 |
Keywords
- AGET
- Atom transfer radical polymerisation
- Bioconjugate
- Biomolecules
- Click chemistry
- DP
- Functionality
- Inverse miniemulsion
ASJC Scopus subject areas
- Condensed Matter Physics
- Physical and Theoretical Chemistry
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry