Biotin-, pyrene-, and GRGDS-functionalized polymers and nanogels via ATRP and end group modification

Daniel J. Siegwart, Jung Kwon Oh, Haifeng Gao, Sidi A. Bencherif, Fabien Perineau, Andrew K. Bohaty, Jeffrey O. Hollinger, Krzysztof Matyjaszewski

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Functionality, one of the key attributes of atom transfer radical polymerization (ATRP), was utilized for the synthesis of well-controlled polymers functionalized with biotin, pyrene, and peptides. Hydroxy- functionalized poly(oligo(ethylene oxide) monomethyl ether methacrylate) (HO-POEOMA) was prepared by AGET ATRP of OEOMA initiated by 2-hydroxyethyl 2-bromoisobutyrate in water or in inverse miniemulsion of water/cyclohexane at ambient temperature. HO-POEOMA was then further functionalized with biotin, pyrene, and GRGDS peptide. In addition, ATRP and click chemistry offered an efficient route for the synthesis of telechelic di-biotin polymers. These general methods can be applied to the formation of different functional materials conjugated with proteins, dyes, nucleic acids, and drugs.

Original languageEnglish (US)
Pages (from-to)2179-2193
Number of pages15
JournalMacromolecular Chemistry and Physics
Issue number21
StatePublished - Nov 6 2008


  • AGET
  • Atom transfer radical polymerisation
  • Bioconjugate
  • Biomolecules
  • Click chemistry
  • DP
  • Functionality
  • Inverse miniemulsion

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry


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