Abstract
Coupling gene activity to the formation of condensates is proposed to enable the robust and precise changes in gene expression during development. In this review, Benjamin Sabari describes the emerging role of condensates in gene activation, the features of macromolecules enabling this process, condensate regulation in development, and condensate dysregulation in diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 84-96 |
| Number of pages | 13 |
| Journal | Developmental cell |
| Volume | 55 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 12 2020 |
Keywords
- biomolecular condensates
- gene regulation
- gene regulation in development and disease
- phase separation
ASJC Scopus subject areas
- Molecular Biology
- General Biochemistry, Genetics and Molecular Biology
- Developmental Biology
- Cell Biology