@article{6c43d448b4834fb4b6d71f97a0473068,
title = "Beyond Molecular Codes: Simple Rules to Wire Complex Brains",
abstract = "Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental algorithms. We explore how molecules and mechanisms that have been considered part of a code may alternatively implement simple pattern formation rules sufficient to ensure wiring specificity in neural circuits. This analysis delineates a pattern-based framework for circuit construction that may contribute to our understanding of brain wiring.",
author = "Hassan, {Bassem A.} and Hiesinger, {P. Robin}",
note = "Funding Information: We would like to thank our laboratories and many friends and colleagues for enduring discussions leading to this text. In particular, we want to thank for critical and very valuable discussions and comments on this article: Tom Clandinin, Alex Kolodkin, Dietmar Schmucker, Nevine Shalaby, Steven Altschuler, Lani Wu, and Joris de Wit. Work in the Hassan laboratory is funded by VIB, University of Leuven, FWO (G.0503.12), belspo (WiBrain Network), EMBO, and the European Commission{\textquoteright}s Marie Sk{\l}odowska Curie programs. Work in the Hiesinger laboratory at the Freie Universit{\"a}t Berlin is funded by the NeuroCure Cluster of Excellence, the NIH (RO1EY018884, RO1EY023333), the Muscular Dystrophy Association, the Deutsche Forschungsgemeinschaft (SFB958), and the FU Berlin. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = oct,
day = "8",
doi = "10.1016/j.cell.2015.09.031",
language = "English (US)",
volume = "163",
pages = "285--291",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}