Abstract
Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental algorithms. We explore how molecules and mechanisms that have been considered part of a code may alternatively implement simple pattern formation rules sufficient to ensure wiring specificity in neural circuits. This analysis delineates a pattern-based framework for circuit construction that may contribute to our understanding of brain wiring.
Original language | English (US) |
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Pages (from-to) | 285-291 |
Number of pages | 7 |
Journal | Cell |
Volume | 163 |
Issue number | 2 |
DOIs | |
State | Published - Oct 8 2015 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology