TY - JOUR
T1 - Beclin orthologs
T2 - Integrative hubs of cell signaling, membrane trafficking, and physiology
AU - Levine, Beth
AU - Liu, Rong
AU - Dong, Xiaonan
AU - Zhong, Qing
N1 - Funding Information:
We thank Haley Harrington for assistance with manuscript preparation and Angela Diehl for expert scientific illustration. This work was supported by National Institutes of Health grants RO1 CA109618 (B.L.), RO1 CA133228 (Q.Z.), and U19AI109725 (B.L.); The Welch Foundation I-1864 (Q.Z.); CPRIT RP120718 (B.L.); and RP140320 (Q.Z.); and the American Cancer Society Research Scholar Grant RSG-11-274-01-CCG (Q.Z.). We apologize to those authors whose work could not be cited owing to space limitations.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The Beclin family, including yeast Atg6 (autophagy related gene 6), its orthologs in higher eukaryotic species, and the more recently characterized mammalian-specific Beclin 2, are essential molecules in autophagy and other membrane-trafficking events. Extensive studies of Beclin orthologs have provided considerable insights into the regulation of autophagy, the diverse roles of autophagy in physiology and disease, and potential new strategies to modulate autophagy in a variety of clinical diseases. In this review we discuss the functions of Beclin orthologs, the regulation of such functions by diverse cellular signaling pathways, and the effects of such regulation on downstream cellular processes including tumor suppression and metabolism. These findings suggest that Beclin orthologs serve as crucial molecules that integrate diverse environmental signals with membrane trafficking events to ensure optimal responses of the cell to stressful stimuli.
AB - The Beclin family, including yeast Atg6 (autophagy related gene 6), its orthologs in higher eukaryotic species, and the more recently characterized mammalian-specific Beclin 2, are essential molecules in autophagy and other membrane-trafficking events. Extensive studies of Beclin orthologs have provided considerable insights into the regulation of autophagy, the diverse roles of autophagy in physiology and disease, and potential new strategies to modulate autophagy in a variety of clinical diseases. In this review we discuss the functions of Beclin orthologs, the regulation of such functions by diverse cellular signaling pathways, and the effects of such regulation on downstream cellular processes including tumor suppression and metabolism. These findings suggest that Beclin orthologs serve as crucial molecules that integrate diverse environmental signals with membrane trafficking events to ensure optimal responses of the cell to stressful stimuli.
KW - Autophagic maturation
KW - Autophagy
KW - Endocytic maturation
KW - Endolysosomal trafficking
KW - LC3-associated phagocytosis
UR - http://www.scopus.com/inward/record.url?scp=84940467196&partnerID=8YFLogxK
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U2 - 10.1016/j.tcb.2015.05.004
DO - 10.1016/j.tcb.2015.05.004
M3 - Review article
C2 - 26071895
AN - SCOPUS:84940467196
SN - 0962-8924
VL - 25
SP - 533
EP - 544
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 9
ER -