@article{3eee82f9356146a4ab3459c2eb0682d8,
title = "Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease",
abstract = "Organelles cooperate with each other to control cellular homeostasis and cell functions by forming close connections through membrane contact sites. Important contacts are present between the endoplasmic reticulum (ER), the main intracellular Ca2+-storage organelle, and the mitochondria, the organelle responsible not only for the majority of cellular ATP production but also for switching on cell death processes. Several Ca2+-transport systems focalize at these contact sites, thereby enabling the efficient transmission of Ca2+ signals from the ER toward mitochondria. This provides tight control of mitochondrial functions at the microdomain level. Here, we discuss how ER–mitochondrial Ca2+ transfers support cell function and how their dysregulation underlies, drives, or contributes to pathogenesis and pathophysiology, with a major focus on cancer and neurodegeneration but also with attention to other diseases such as diabetes and rare genetic diseases.",
keywords = "Ca signaling, MAMs, cancer, contact sites, genetic diseases, neurodegeneration",
author = "Jens Loncke and Allen Kaasik and Ilya Bezprozvanny and Parys, {Jan B.} and Martijn Kerkhofs and Geert Bultynck",
note = "Funding Information: Research in the authors{\textquoteright} laboratories was supported by research grants from the Research Foundation – Flanders (FWO) (G.0A34.16N, G.0901.18N, and G.0818.21N to G.B.; grant G0E7520N to G.B. and I.B.; grant G.0C91.14N to G.B. and J.B.P.; and grant G0A6919N to J.B.P.), the Research Council – KU Leuven (OT14/101and AKUL/19/34 to G.B. and C14/19/101 to G.B. and J.B.P.), the Central European Leuven Strategic Alliance (CELSA/18/040 to G.B. and A.K.), Stichting Alzheimer Onderzoek (SAO IP3 RECEPTOR to G.B.), the Eye Hope Foundation/Koning Boudewijnstichting (2020-J1160630-214966 to G.B.), the Russian Science Foundation (grant 20-45-01004 to I.B.), and the National Institutes of Health (grants R01AG055577 and R01NS056224 to I.B.). M.K. obtained a doctoral fellowship from the FWO. A.K. is also supported by the Estonian Research Council (PRG400) and the European Regional Development Fund (2014-2020.4.01.15-0012). I.B. is a holder of the Carl J. and Hortense M. Thomsen Chair in Alzheimer's Disease Research. We apologize to all authors whose work could not be cited due to space restrictions. The authors declare no competing interests. Funding Information: Research in the authors{\textquoteright} laboratories was supported by research grants from the Research Foundation – Flanders (FWO) (G.0A34.16N, G.0901.18N, and G.0818.21N to G.B.; grant G0E7520N to G.B. and I.B.; grant G.0C91.14N to G.B. and J.B.P.; and grant G0A6919N to J.B.P.), the Research Council – KU Leuven (OT14/101and AKUL/19/34 to G.B. and C14/19/101 to G.B. and J.B.P.), the Central European Leuven Strategic Alliance (CELSA/18/040 to G.B. and A.K.), Stichting Alzheimer Onderzoek (SAO IP3 RECEPTOR to G.B.), the Eye Hope Foundation / Koning Boudewijnstichting (2020-J1160630-214966 to G.B.), the Russian Science Foundation (grant 20-45-01004 to I.B.), and the National Institutes of Health (grants R01AG055577 and R01NS056224 to I.B.). M.K. obtained a doctoral fellowship from the FWO. A.K. is also supported by the Estonian Research Council (PRG400) and the European Regional Development Fund (2014-2020.4.01.15-0012). I.B. is a holder of the Carl J. and Hortense M. Thomsen Chair in Alzheimer{\textquoteright}s Disease Research. We apologize to all authors whose work could not be cited due to space restrictions. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = jul,
doi = "10.1016/j.tcb.2021.02.003",
language = "English (US)",
volume = "31",
pages = "598--612",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "7",
}