Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus

C. E. Haley, M. Marling-Cason, J. W. Smith, J. P. Luby, P. A. Mackowiak

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102 Scopus citations


Various commonly used antiseptics were tested against three strains of methicillin-resistant Staphylococcus aureus (MRSA) at stock strength and in serial 10-fold dilutions. The stock solutions of 4% chlorhexidine gluconate-alcohol (Hibiclens), 1% p-chloro-m-xylenol (Acute-Kare), and 3% hexachlorophene (Phisohex) produced 2-log reductions of MRSA after a 15-s exposure, but even after 240 s, these solutions failed to kill all the MRSA. Povidone-iodine (Betadine) solution was maximally effected at the 1:100 dilution, killing all the MRSA within 15 s; other dilutions were less effective, though each killed the MRSA within 120 s. Similar results were obtained with three different strains of methicillin-susceptible S. aureus. Thus, of the four most commonly used antiseptics, providone-iodine, when diluted 1:100, was the most rapidly bactericidal against both MRSA and methicillin-susceptible S. aureus.

Original languageEnglish (US)
Pages (from-to)991-992
Number of pages2
JournalJournal of clinical microbiology
Issue number6
StatePublished - 1985

ASJC Scopus subject areas

  • Microbiology (medical)


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