Abstract
B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies have provided evidence for inhibitory functions of both members via PD-1. Meanwhile, compelling evidence exists for costimulatory function of both members. Here we demonstrate that expression of B7DC on the tumor cells promotes CD8 T cell-mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, B7DC binds to PD-1(-/-) cells and enhances T cell killing in a PD-1-independent mechanism. Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC.
Original language | English (US) |
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Pages (from-to) | 1721-1730 |
Number of pages | 10 |
Journal | Journal of Experimental Medicine |
Volume | 197 |
Issue number | 12 |
DOIs | |
State | Published - Jun 16 2003 |
Keywords
- Costimulatory molecules
- Cytolytic T lymphocytes
- Tumor immunity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology