Abstract
B cells are highly potent antigen presenting cells of their cognate antigens. However, it remains unknown whether B cells can orchestrate Th17-mediated responses against neuro-antigens. We report that MS patients and healthy donors had a similar frequency of antigen-specific Th1 and Th17 cells, and distribution of T effector and T central memory cells. Notwithstanding these similarities, the application of an in vitro assay demonstrated that the B cells derived from a subset of MS patients exhibited the capability of coordinating Th17 responses directed toward neuro-antigens. These observations underscore the B cell's contribution to the putative underpinnings of multiple sclerosis.
Original language | English (US) |
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Pages (from-to) | 46-53 |
Number of pages | 8 |
Journal | Journal of Neuroimmunology |
Volume | 291 |
DOIs | |
State | Published - Feb 15 2016 |
Keywords
- B cells
- Multiple sclerosis
- Th17 cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology