B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma

Rodrigo Javier; Nawal Shaikh; Maciej S. Lesniak; Adam Sonabend; Roger Stupp; Amir Behdad; Craig Horbinski

doi:10.1186/s13000-018-0717-9

B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma

Rodrigo Javier, Nawal Shaikh, Maciej S. Lesniak, Adam Sonabend, Roger Stupp, Amir Behdad, Craig Horbinski

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Primary central nervous system lymphoma (PCNSL) is an uncommon tumor in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have been described in which the first detected intracerebral lesions are non-neoplastic, and are composed mostly of perivascular T cells, not B cells. This phenomenon is known as "sentinel lesions."

Original language	English (US)
Article number	37
Journal	Diagnostic Pathology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s13000-018-0717-9
State	Published - Jun 5 2018
Externally published	Yes

Keywords

Diffuse large B cell lymphoma
Primary CNS lymphoma
Sentinel lesion

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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10.1186/s13000-018-0717-9

Cite this

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title = "B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma",

abstract = "Background: Primary central nervous system lymphoma (PCNSL) is an uncommon tumor in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have been described in which the first detected intracerebral lesions are non-neoplastic, and are composed mostly of perivascular T cells, not B cells. This phenomenon is known as {"}sentinel lesions.{"}",

keywords = "Diffuse large B cell lymphoma, Primary CNS lymphoma, Sentinel lesion",

author = "Rodrigo Javier and Nawal Shaikh and Lesniak, {Maciej S.} and Adam Sonabend and Roger Stupp and Amir Behdad and Craig Horbinski",

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doi = "10.1186/s13000-018-0717-9",

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T1 - B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma

AU - Javier, Rodrigo

AU - Shaikh, Nawal

AU - Lesniak, Maciej S.

AU - Sonabend, Adam

AU - Stupp, Roger

AU - Behdad, Amir

AU - Horbinski, Craig

PY - 2018/6/5

Y1 - 2018/6/5

N2 - Background: Primary central nervous system lymphoma (PCNSL) is an uncommon tumor in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have been described in which the first detected intracerebral lesions are non-neoplastic, and are composed mostly of perivascular T cells, not B cells. This phenomenon is known as "sentinel lesions."

AB - Background: Primary central nervous system lymphoma (PCNSL) is an uncommon tumor in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have been described in which the first detected intracerebral lesions are non-neoplastic, and are composed mostly of perivascular T cells, not B cells. This phenomenon is known as "sentinel lesions."

KW - Diffuse large B cell lymphoma

KW - Primary CNS lymphoma

KW - Sentinel lesion

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ER -

B cell-rich non-neoplastic sentinel lesion preceding primary central nervous system lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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