Axonal multifocal motor neuropathy without conduction block or other features of demyelination

J. S. Katz, R. J. Barohn, S. Kojan, G. I. Wolfe, S. P. Nations, D. S. Saperstein, A. A. Amato

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


Background: Conduction block is considered an essential finding for the distinction between motor neuropathies and lower motor neuron disorders. Only a small number of reports describe patients with multifocal motor neuropathies who lack overt conduction block, although in these cases other features of demyelination still suggest the presence of a demyelinating disorder. In contrast, a purely axonal multifocal motor neuropathy has not been described. Methods: This report describes nine patients with slowly or nonprogressive multifocal motor neuropathies who had purely axonal electrodiagnostic features. Results: GM1 antibodies titers were normal in all nine cases. Six patients were treated with either prednisone or IV immunoglobulin and three showed convincing improvement. Conclusions: These findings suggest an immune-mediated motor neuropathy with axonal electrophysiologic features that appears to be distinct from both multifocal motor neuropathy and established motor neuron disorders.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
Issue number4
StatePublished - Feb 26 2002

ASJC Scopus subject areas

  • Clinical Neurology


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