Autophagy in metazoans: Cell survival in the land of plenty

Julian J. Lum, Ralph J. DeBerardinis, Craig B. Thompson

Research output: Contribution to journalReview articlepeer-review

672 Scopus citations


Cells require a constant supply of macromolecular precursors and oxidizable substrates to maintain viability. Unicellular eukaryotes lack the ability to regulate nutrient concentrations in their extracellular environment. So when environmental nutrients are depleted, these organisms catabolize existing cytoplasmic components to support ATP production to maintain survival, a process known as autophagy. By contrast, the environment of metazoans normally contains abundant extracellular nutrients, but a cell's ability to take up these nutrients is controlled by growth factor signal transduction. Despite evolving the ability to maintain a constant supply of extracellular nutrients, metazoans have retained a complete set of autophagy genes. The physiological relevance of autophagy in such species is just beginning to be explored.

Original languageEnglish (US)
Pages (from-to)439-448
Number of pages10
JournalNature Reviews Molecular Cell Biology
Issue number6
StatePublished - Jun 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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