TY - JOUR
T1 - Autophagy in C. elegans.
AU - Meléndez, Alicia
AU - Levine, Beth
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2009
Y1 - 2009
N2 - Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through an autophagosomal-lysosomal pathway. Genetic screens, primarily in S. cerevisiae, have identified numerous genes that are essential for autophagy. Many of these genes have orthologs in higher eukaryotes, including C. elegans, Drosophila, and mammals. Gene knockdown/knockout studies in C. elegans have been useful to probe the functions of autophagy in an intact multicellular organism that undergoes development to produce different cell types. This review summarizes important themes that have emerged regarding the roles of autophagy in C. elegans in adaptation to stress, aging, normal reproductive growth, cell death, cell growth control, neural synaptic clustering, and the degradation of aggregate-prone proteins.
AB - Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through an autophagosomal-lysosomal pathway. Genetic screens, primarily in S. cerevisiae, have identified numerous genes that are essential for autophagy. Many of these genes have orthologs in higher eukaryotes, including C. elegans, Drosophila, and mammals. Gene knockdown/knockout studies in C. elegans have been useful to probe the functions of autophagy in an intact multicellular organism that undergoes development to produce different cell types. This review summarizes important themes that have emerged regarding the roles of autophagy in C. elegans in adaptation to stress, aging, normal reproductive growth, cell death, cell growth control, neural synaptic clustering, and the degradation of aggregate-prone proteins.
UR - http://www.scopus.com/inward/record.url?scp=70449707473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449707473&partnerID=8YFLogxK
U2 - 10.1895/wormbook.1.147.1
DO - 10.1895/wormbook.1.147.1
M3 - Review article
C2 - 19705512
AN - SCOPUS:70449707473
SN - 1551-8507
SP - 1
EP - 26
JO - WormBook : the online review of C. elegans biology
JF - WormBook : the online review of C. elegans biology
ER -