Autophagy, Immunity, and Microbial Adaptations

Vojo Deretic, Beth Levine

Research output: Contribution to journalReview articlepeer-review

706 Scopus citations


Autophagy adjusts cellular biomass and function in response to diverse stimuli, including infection. Autophagy plays specific roles in shaping immune system development, fueling host innate and adaptive immune responses, and directly controlling intracellular microbes as a cell-autonomous innate defense. As an evolutionary counterpoint, intracellular pathogens have evolved to block autophagic microbicidal defense and subvert host autophagic responses for their survival or growth. The ability of eukaryotic pathogens to deploy their own autophagic machinery may also contribute to microbial pathogenesis. Thus, a complex interplay between autophagy and microbial adaptations against autophagy governs the net outcome of host-microbe encounters.

Original languageEnglish (US)
Pages (from-to)527-549
Number of pages23
JournalCell Host and Microbe
Issue number6
StatePublished - Jun 18 2009



ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology


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