TY - CHAP
T1 - Autophagy and longevity
T2 - Lessons from C. elegans
AU - Jia, Kailiang
AU - Levine, Beth
PY - 2010
Y1 - 2010
N2 - Aging is a process in which individuals undergo an exponential decline in vitality, leading to death. In the last two decades, the study of the molecular regulation of aging in model organisms, particularly in C. elegans, has greatly expanded our knowledge of aging. Multiple longevity pathways, such as insulin-like growth factor signaling, TOR signaling, dietary restriction and mitochondrial activity, control aging in C. elegans. Recent genetic studies indicate that autophagy, an evolutionary conserved lysosomal degradation pathway, interacts with various longevity signals in the regulation of C. elegans life span. Here, we review the current progress in understanding the role of autophagy in the regulation of C. elegans life span.
AB - Aging is a process in which individuals undergo an exponential decline in vitality, leading to death. In the last two decades, the study of the molecular regulation of aging in model organisms, particularly in C. elegans, has greatly expanded our knowledge of aging. Multiple longevity pathways, such as insulin-like growth factor signaling, TOR signaling, dietary restriction and mitochondrial activity, control aging in C. elegans. Recent genetic studies indicate that autophagy, an evolutionary conserved lysosomal degradation pathway, interacts with various longevity signals in the regulation of C. elegans life span. Here, we review the current progress in understanding the role of autophagy in the regulation of C. elegans life span.
UR - http://www.scopus.com/inward/record.url?scp=78049354315&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049354315&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-7002-2_5
DO - 10.1007/978-1-4419-7002-2_5
M3 - Chapter
C2 - 20886756
AN - SCOPUS:78049354315
SN - 9781441970015
T3 - Advances in Experimental Medicine and Biology
SP - 47
EP - 60
BT - Protein Metabolism and Homeostasis in Aging
A2 - Tavernarakis, Nektarios
ER -