Autophagosome–lysosome fusion: PIs to the rescue

Linsen Li; Qing Zhong

doi:10.15252/embj.201695134

Autophagosome–lysosome fusion: PIs to the rescue

Linsen Li, Qing Zhong

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P₂ at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.

Original language	English (US)
Pages (from-to)	1845-1847
Number of pages	3
Journal	EMBO Journal
Volume	35
Issue number	17
DOIs	https://doi.org/10.15252/embj.201695134
State	Published - Sep 1 2016

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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title = "Autophagosome–lysosome fusion: PIs to the rescue",

abstract = "Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.",

author = "Linsen Li and Qing Zhong",

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AU - Zhong, Qing

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AB - Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.

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Autophagosome–lysosome fusion: PIs to the rescue

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