Autophagosome–lysosome fusion: PIs to the rescue

Linsen Li, Qing Zhong

Research output: Contribution to journalComment/debatepeer-review

6 Scopus citations


Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5-phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3,5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.

Original languageEnglish (US)
Pages (from-to)1845-1847
Number of pages3
JournalEMBO Journal
Issue number17
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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