TY - JOUR
T1 - Atypical presentations of thrombotic thrombocytopenic purpura
T2 - A review
AU - Sarode, Ravi
PY - 2009
Y1 - 2009
N2 - Thrombotic thrombocytopenic purpura (TTP) is diagnosed by the presence of microangiopathic hemolytic anemia and thrombocytopenia in a patient who frequently presents with central nervous system involvement and, to a lesser extent, renal dysfunction. Recent understanding of the pathophysiology of TTP due to severe deficiency of von Willebrand factor cleaving protease, known as ADAMTS13, has improved diagnosis of TTP. Once the diagnosis is suspected, life-saving therapeutic plasma exchange therapy is initiated. Occasionally, an unusual clinical presentation makes TTP diagnosis difficult, thus resulting in a delay in the management of TTP. This review highlights a variety of atypical TTP presentations described in the literature. It is intended to bring unusual scenarios to the clinician's awareness, so that timely treatment can be delivered.
AB - Thrombotic thrombocytopenic purpura (TTP) is diagnosed by the presence of microangiopathic hemolytic anemia and thrombocytopenia in a patient who frequently presents with central nervous system involvement and, to a lesser extent, renal dysfunction. Recent understanding of the pathophysiology of TTP due to severe deficiency of von Willebrand factor cleaving protease, known as ADAMTS13, has improved diagnosis of TTP. Once the diagnosis is suspected, life-saving therapeutic plasma exchange therapy is initiated. Occasionally, an unusual clinical presentation makes TTP diagnosis difficult, thus resulting in a delay in the management of TTP. This review highlights a variety of atypical TTP presentations described in the literature. It is intended to bring unusual scenarios to the clinician's awareness, so that timely treatment can be delivered.
KW - Ccute MI
KW - Rituximab
KW - Stroke
KW - Thrombotic thrombocytopenic purpura
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U2 - 10.1002/jca.20182
DO - 10.1002/jca.20182
M3 - Review article
C2 - 19073011
AN - SCOPUS:63249107524
SN - 0733-2459
VL - 24
SP - 47
EP - 52
JO - Journal of Clinical Apheresis
JF - Journal of Clinical Apheresis
IS - 1
ER -