Asynchrony in executive networks predicts cognitive slowing in multiple sclerosis

Nicholas A. Hubbard; Joanna L. Hutchison; Monroe P. Turner; Saranya Sundaram; Larry Oasay; Diana Robinson; Jeremy Strain; Travis Weaver; Scott L. Davis; Gina M. Remington; Hao Huang; Bharat B. Biswal; John Hart; Teresa C. Frohman; Elliot Frohman; Bart Rypma

doi:10.1037/neu0000202

Asynchrony in executive networks predicts cognitive slowing in multiple sclerosis

Nicholas A. Hubbard, Joanna L. Hutchison, Monroe P. Turner, Saranya Sundaram, Larry Oasay, Diana Robinson, Jeremy Strain, Travis Weaver, Scott L. Davis, Gina M. Remington, Hao Huang, Bharat B. Biswal, John Hart, Teresa C. Frohman, Elliot Frohman, Bart Rypma

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Objective: Cognitive slowing is a core neuropsychological symptom of Multiple Sclerosis (MS). We aimed to assess the extent to which cognitive slowing in MS was predicted by changes in dorsolateral prefrontal networks. Method: We assessed patients with relapsing-remitting MS and healthy controls (HCs) on measures of processing speed. Participants underwent a functional MRI while performing a processing speed task to allow assessment of task-based connectivity. Results: Patients were slower than HCs on the processing speed tasks. Patients showed attenuated connectivity between right and left dorsolateral prefrontal cortex (DLPFC) and task-relevant brain regions compared to HCs during processing speed task performance. Patients' connectivity with DLPFC in these group-disparate networks accounted for significant variability in their performance on processing speed measures administered both in and out of the imaging environment. Specifically, patients who had stronger functional connections with DLPFC in group-disparate networks performed faster than patients with weaker connections with DLPFC in group-disparate networks. Conclusion: Results suggest that MS-related cognitive slowing can be accounted for by systemic alterations in executive functional networks.

Original language	English (US)
Pages (from-to)	75-86
Number of pages	12
Journal	Neuropsychology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1037/neu0000202
State	Published - Jan 1 2016

Keywords

Executive networks
FMRI
Multiple sclerosis
Prefrontal cortex
Processing speed

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology

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10.1037/neu0000202

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Hubbard, N. A., Hutchison, J. L., Turner, M. P., Sundaram, S., Oasay, L., Robinson, D., Strain, J., Weaver, T., Davis, S. L., Remington, G. M., Huang, H., Biswal, B. B., Hart, J., Frohman, T. C., Frohman, E., & Rypma, B. (2016). Asynchrony in executive networks predicts cognitive slowing in multiple sclerosis. Neuropsychology, 30(1), 75-86. https://doi.org/10.1037/neu0000202

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title = "Asynchrony in executive networks predicts cognitive slowing in multiple sclerosis",

abstract = "Objective: Cognitive slowing is a core neuropsychological symptom of Multiple Sclerosis (MS). We aimed to assess the extent to which cognitive slowing in MS was predicted by changes in dorsolateral prefrontal networks. Method: We assessed patients with relapsing-remitting MS and healthy controls (HCs) on measures of processing speed. Participants underwent a functional MRI while performing a processing speed task to allow assessment of task-based connectivity. Results: Patients were slower than HCs on the processing speed tasks. Patients showed attenuated connectivity between right and left dorsolateral prefrontal cortex (DLPFC) and task-relevant brain regions compared to HCs during processing speed task performance. Patients' connectivity with DLPFC in these group-disparate networks accounted for significant variability in their performance on processing speed measures administered both in and out of the imaging environment. Specifically, patients who had stronger functional connections with DLPFC in group-disparate networks performed faster than patients with weaker connections with DLPFC in group-disparate networks. Conclusion: Results suggest that MS-related cognitive slowing can be accounted for by systemic alterations in executive functional networks.",

keywords = "Executive networks, FMRI, Multiple sclerosis, Prefrontal cortex, Processing speed",

author = "Hubbard, {Nicholas A.} and Hutchison, {Joanna L.} and Turner, {Monroe P.} and Saranya Sundaram and Larry Oasay and Diana Robinson and Jeremy Strain and Travis Weaver and Davis, {Scott L.} and Remington, {Gina M.} and Hao Huang and Biswal, {Bharat B.} and John Hart and Frohman, {Teresa C.} and Elliot Frohman and Bart Rypma",

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year = "2016",

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doi = "10.1037/neu0000202",

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AU - Hubbard, Nicholas A.

AU - Hutchison, Joanna L.

AU - Turner, Monroe P.

AU - Sundaram, Saranya

AU - Oasay, Larry

AU - Robinson, Diana

AU - Strain, Jeremy

AU - Weaver, Travis

AU - Davis, Scott L.

AU - Remington, Gina M.

AU - Huang, Hao

AU - Biswal, Bharat B.

AU - Hart, John

AU - Frohman, Teresa C.

AU - Frohman, Elliot

AU - Rypma, Bart

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objective: Cognitive slowing is a core neuropsychological symptom of Multiple Sclerosis (MS). We aimed to assess the extent to which cognitive slowing in MS was predicted by changes in dorsolateral prefrontal networks. Method: We assessed patients with relapsing-remitting MS and healthy controls (HCs) on measures of processing speed. Participants underwent a functional MRI while performing a processing speed task to allow assessment of task-based connectivity. Results: Patients were slower than HCs on the processing speed tasks. Patients showed attenuated connectivity between right and left dorsolateral prefrontal cortex (DLPFC) and task-relevant brain regions compared to HCs during processing speed task performance. Patients' connectivity with DLPFC in these group-disparate networks accounted for significant variability in their performance on processing speed measures administered both in and out of the imaging environment. Specifically, patients who had stronger functional connections with DLPFC in group-disparate networks performed faster than patients with weaker connections with DLPFC in group-disparate networks. Conclusion: Results suggest that MS-related cognitive slowing can be accounted for by systemic alterations in executive functional networks.

AB - Objective: Cognitive slowing is a core neuropsychological symptom of Multiple Sclerosis (MS). We aimed to assess the extent to which cognitive slowing in MS was predicted by changes in dorsolateral prefrontal networks. Method: We assessed patients with relapsing-remitting MS and healthy controls (HCs) on measures of processing speed. Participants underwent a functional MRI while performing a processing speed task to allow assessment of task-based connectivity. Results: Patients were slower than HCs on the processing speed tasks. Patients showed attenuated connectivity between right and left dorsolateral prefrontal cortex (DLPFC) and task-relevant brain regions compared to HCs during processing speed task performance. Patients' connectivity with DLPFC in these group-disparate networks accounted for significant variability in their performance on processing speed measures administered both in and out of the imaging environment. Specifically, patients who had stronger functional connections with DLPFC in group-disparate networks performed faster than patients with weaker connections with DLPFC in group-disparate networks. Conclusion: Results suggest that MS-related cognitive slowing can be accounted for by systemic alterations in executive functional networks.

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Asynchrony in executive networks predicts cognitive slowing in multiple sclerosis

Abstract

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