Abstract
A rhodium-catalyzed asymmetric hydroboration of enol carbamates yields E-boryl carbamates with a good enantioselectivity. The enol carbamate starting materials can be prepared with moderate Z-selectivity by using a modified Juila olefination; they can then be used as the resulting E/Z mixtures, taking advantage of the faster reactivity of the major Z-isomers in the directed hydroboration. Optically active E-boryl carbamates participate in a Matteson-type homologation with Grignard reagents, in which the O-carbamate is substituted, with high conservation of optical activity, to provide enantioenriched secondary boronic esters.
Original language | English (US) |
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Pages (from-to) | 2181-2186 |
Number of pages | 6 |
Journal | Synlett |
Volume | 34 |
Issue number | 18 |
DOIs | |
State | Published - May 10 2023 |
Keywords
- Julia olefination
- Matteson homologation
- boronic esters
- hydroboration
- rhodium catalysis
ASJC Scopus subject areas
- Organic Chemistry