@article{fd0ad3b9a7194846a7e2698fca5b41b4,
title = "Association of accelerometry-measured physical activity and cardiovascular events in mobility-limited older adults: The LIFE (Lifestyle Interventions and Independence for Elders) study",
abstract = "Background--Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older adults in the LIFE (Lifestyle Interventions and Independence for Elders) study. Methods and Results--Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis. Home-based activity data were collected by hip-worn accelerometers at baseline and at 6, 12, and 24 months postrandomization to either a physical activity or health education intervention. LIFE study participants (n=1590; age 78.9±5.2 [SD] years; 67.2% women) at baseline had an 11% lower incidence of experiencing a subsequent cardiovascular event per 500 steps taken per day based on activity data (hazard ratio, 0.89; 95% confidence interval, 0.84-0.96; P=0.001). At baseline, every 30 minutes spent performing activities ≥500 counts per minute (hazard ratio, 0.75; confidence interval, 0.65-0.89 [P=0.001]) were also associated with a lower incidence of cardiovascular events. Throughout follow-up (6, 12, and 24 months), both the number of steps per day (per 500 steps; hazard ratio, 0.90, confidence interval, 0.85-0.96 [P=0.001]) and duration of activity ≥500 counts per minute (per 30 minutes; hazard ratio, 0.76; confidence interval, 0.63-0.90 [P=0.002]) were significantly associated with lower cardiovascular event rates. Conclusions--Objective measurements of physical activity via accelerometry were associated with cardiovascular events among older adults with limited mobility (summary score > 10 on the Short Physical Performance Battery) both using baseline and longitudinal data.",
keywords = "Accelerometry, Aging, Cardiovascular, Physical activity",
author = "{for the LIFE Study Research Group} and Cochrane, {Shannon K.} and Chen, {Shyh Huei} and Fitzgerald, {Jodi D.} and Dodson, {John A.} and Fielding, {Roger A.} and King, {Abby C.} and McDermott, {Mary M.} and Manini, {Todd M.} and Marsh, {Anthony P.} and Newman, {Anne B.} and Marco Pahor and Catrine Tudor-Locke and Ambrosius, {Walter T.} and Buford, {Thomas W.} and Guralnik, {Jack M.} and Christiaan Leeuwenburgh and Connie Caudle and Lauren Crump and Latonia Holmes and Jocelyn Lee and Lu, {Ching Ju} and Miller, {Michael E.} and Espeland, {Mark A.} and William Applegate and Beavers, {Daniel P.} and Byington, {Robert P.} and Delilah Cook and Furberg, {Curt D.} and Harvin, {Lea N.} and Leora Henkin and John Hepler and Hsu, {Fang Chi} and Laura Lovato and Wesley Roberson and Julia Rushing and Scott Rushing and Stowe, {Cynthia L.} and Walkup, {Michael P.} and Don Hire and {Jack Rejeski}, W. and Katula, {Jeffrey A.} and Brubaker, {Peter H.} and Mihalko, {Shannon L.} and Jennings, {Janine M.} and Pierce, {June J.} and Hadley, {Evan C.} and Sergei Romashkan and Patel, {Kushang V.} and Denise Bonds and Diana Kerwin",
note = "Funding Information: The LIFE study is funded by a National Institutes of Health/ National Institute on Aging Cooperative Agreement #U01 AG22376 and a supplement from the National Heart, Lung, and Blood Institute 3U01AG022376-05A2S, and sponsored in part by the Intramural Research Program, National Institute on Aging, NIH. The research is also partially supported by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (1 P30 AG028740), Tufts University (1P30AG031679), University of Pittsburgh (P30 AG024827), Wake Forest University (P30AG021332), and Yale University (P30AG021342) and the NIH/NCRR CTSA at Stanford University (UL1 RR025744). Tufts University is also supported by the Boston Rehabilitation Outcomes Center (1R24HD065688-01A1). LIFE investigators are also partially supported by the following: Dr Thomas Gill (Yale University) is the recipient of an Academic Leadership Award (K07AG3587) from the National Institute on Aging. Dr Carlos Fragoso (Spirometry Reading Center, Yale University) is the recipient of a Career Development Award from the Department of Veterans Affairs. Dr Roger Fielding (Tufts University) is partially supported by the US Department of Agriculture, under agreement No. 58-1950-0-014. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the US Department of Agriculture. Publisher Copyright: {\textcopyright} 2017 The Authors.",
year = "2017",
month = dec,
day = "1",
doi = "10.1161/JAHA.117.007215",
language = "English (US)",
volume = "6",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "12",
}