Association of a Novel Protocol for Rapid Exclusion of Myocardial Infarction with Resource Use in a US Safety Net Hospital

Rebecca Vigen, Deborah B. Diercks, Ibrahim A. Hashim, Ambarish Pandey, Lin Zhong, Patricia Kutscher, Fernabelle Fernandez, Amy Yu, Bryan Bertulfo, Kyle Molberg, Jeffery C. Metzger, Jose Soto, Dergham Alzubaidy, Lorie Thibodeaux, Jose A. Joglar, Sandeep R. Das, James A. De Lemos

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Importance: High-sensitivity cardiac troponin T (hs-cTnT) protocols for the evaluation of chest pain in the emergency department (ED) may reduce unnecessary resource use and overcrowding. Objective: To determine whether the implementation of a novel hs-cTnT protocol, which incorporated troponin values drawn at 0, 1, and 3 hours after ED presentation and the modified HEART score (history, electrocardiogram, age, risk factors), was associated with improvements in resource use while maintaining safety. Design, Setting, and Participants: This retrospective cohort study from Parkland Health and Hospital System, a large safety net hospital in Dallas, Texas, included data on 31543 unique ED encounters in which patients underwent electrocardiographic and troponin testing from January 1, 2017, to October 16, 2018. The hs-cTnT protocol was implemented in December 2017. Main Outcomes and Measures: Resource use outcomes included trends in ED dwell time, troponin to disposition decision time (the difference between the first troponin draw time and the time an order was placed for inpatient admission, admission to observation, or discharge), and final patient disposition. Safety outcomes included readmission for myocardial infarction and death. Results: In 31543 encounters, mean (SD) patient age was 54 (14.4) years and 14675 patients (48%) were female. Department dwell time decreased by a mean of -1.09 (95% CI, -2.81 to 0.64) minutes per month in the preintervention period. The decline was steeper after the intervention (-4.69 [95% CI, -9.05 to -0.33] minutes per month) (P for interaction =.007). The troponin to disposition time was increasing in the preintervention period by 1.72 (95% CI, 1.08 to 2.36) minutes per month; postintervention, the mean difference increased more slowly (0.37 [95% CI, -1.25 to 1.99 minutes per month; P value for interaction =.007]). The proportion of patients discharged from the ED increased after the intervention (48% vs 54%, P <.001). Thirty-day major adverse cardiac event rates were low and did not differ before and after the intervention. Conclusions and Relevance: Implementation of a novel protocol incorporating serial hs-cTnT measurements over 3 hours with the Modified HEART Score was associated with reduction in ED dwell times and attenuation of temporal increases in time from troponin measurement to disposition. This or similar protocols to rule out myocardial infarction have the potential to reduce ED overcrowding and improve health care quality while maintaining safety..

Original languageEnglish (US)
Article numbere203359
JournalJAMA Network Open
Issue number4
StatePublished - Apr 22 2020

ASJC Scopus subject areas

  • Medicine(all)


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