Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022

Ralph C. Wang; Michael Gottlieb; Juan Carlos C. Montoy; Robert M. Rodriguez; Huihui Yu; Erica S. Spatz; Christopher W. Chandler; Joann G. Elmore; Paavali A. Hannikainen; Anna Marie Chang; Mandy Hill; Ryan M. Huebinger; Ahamed H. Idris; Katherine Koo; Shu Xia Li; Samuel McDonald; Graham Nichol; Kelli N. O'Laughlin; Ian D. Plumb; Michelle Santangelo; Sharon Saydah; Kari A. Stephens; Arjun K. Venkatesh; Robert A. Weinstein; Robert A. Weinstein; Michelle Santangelo; Katherine Koo; Antonia Derden; Kristyn Gatling; Diego Guzman; Geoffrey Yang; Marshall Kaadan; Minna Hassaballa; Ryan Jerger; Zohaib Ahmed; Michael Choi; Arjun Venkatesh; Erica Spatz; Zhenqiu Lin; Shu Xia Li; Huihui Yu; Mengni Liu; Arjun Venkatesh; Erica Spatz; Andrew Ulrich; Jeremiah Kinsman; Jocelyn Dorney; Senyte Pierce; Xavier Puente; Graham Nichol; Kari Stephens; Jill Anderson; Dana Morse; Karen Adams; Zenoura Maat; Tracy Stober; Kelli N. O'Laughlin; Nikki Gentile; Rachel E. Geyer; Michael Willis; Luis Ruiz; Kerry Malone; Jasmine Park; Kristin Rising; Efrat Kean; Morgan Kelly; Kevin Schaeffer; Lindsey Shughart; Hailey Shughart; Nicole Renzi; Grace Amadio; Dylan Grau; Phillip Watts; David Cheng; Jessica Miao; Carly Shutty; Alex Charlton; Mandy Hill; Ryan Huebinger Site; Summer Chavez; Arun Kane; Peter Nikonowicz; Ahamed H. Idris; Samuel McDonald; David Gallegos; Riley Martin; Joann Elmore; Lauren Wisk; Michelle L'Hommedieu; Chris Chandler; Megan Eguchi; Kate Diaz Roldan; Nicole Villegas; Raul Moreno; Robert Rodriguez; Ralph C. Wang; Juan Carlos Montoy; Robin Kemball; Virginia Chan; Cecilia Lara Chavez; Angela Wong; Mireya Arreguin; Ian D. Plumb; Aron J. Hall; Sharon Saydah; Melissa Briggs-Hagen

doi:10.1093/ofid/ofad275

Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022

Ralph C. Wang, Michael Gottlieb, Juan Carlos C. Montoy, Robert M. Rodriguez, Huihui Yu, Erica S. Spatz, Christopher W. Chandler, Joann G. Elmore, Paavali A. Hannikainen, Anna Marie Chang, Mandy Hill, Ryan M. Huebinger, Ahamed H. Idris, Katherine Koo, Shu Xia Li, Samuel McDonald, Graham Nichol, Kelli N. O'Laughlin, Ian D. Plumb, Michelle SantangeloSharon Saydah, Kari A. Stephens, Arjun K. Venkatesh, Robert A. Weinstein, Robert A. Weinstein, Michelle Santangelo, Katherine Koo, Antonia Derden, Kristyn Gatling, Diego Guzman, Geoffrey Yang, Marshall Kaadan, Minna Hassaballa, Ryan Jerger, Zohaib Ahmed, Michael Choi, Arjun Venkatesh, Erica Spatz, Zhenqiu Lin, Shu Xia Li, Huihui Yu, Mengni Liu, Arjun Venkatesh, Erica Spatz, Andrew Ulrich, Jeremiah Kinsman, Jocelyn Dorney, Senyte Pierce, Xavier Puente, Graham Nichol, Kari Stephens, Jill Anderson, Dana Morse, Karen Adams, Zenoura Maat, Tracy Stober, Kelli N. O'Laughlin, Nikki Gentile, Rachel E. Geyer, Michael Willis, Luis Ruiz, Kerry Malone, Jasmine Park, Kristin Rising, Efrat Kean, Morgan Kelly, Kevin Schaeffer, Lindsey Shughart, Hailey Shughart, Nicole Renzi, Grace Amadio, Dylan Grau, Phillip Watts, David Cheng, Jessica Miao, Carly Shutty, Alex Charlton, Mandy Hill, Ryan Huebinger Site, Summer Chavez, Arun Kane, Peter Nikonowicz, Ahamed H. Idris, Samuel McDonald, David Gallegos, Riley Martin, Joann Elmore, Lauren Wisk, Michelle L'Hommedieu, Chris Chandler, Megan Eguchi, Kate Diaz Roldan, Nicole Villegas, Raul Moreno, Robert Rodriguez, Ralph C. Wang, Juan Carlos Montoy, Robin Kemball, Virginia Chan, Cecilia Lara Chavez, Angela Wong, Mireya Arreguin, Ian D. Plumb, Aron J. Hall, Sharon Saydah, Melissa Briggs-Hagen

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence of acute symptoms across pre-Delta, Delta, and Omicron. Methods: We conducted an analysis of the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. We determined the association between the pre-Delta, Delta, and Omicron time periods and the prevalence of 21 coronavirus disease 2019 (COVID-19) acute symptoms. Results: We enrolled 4113 participants from December 2020 to June 2022. Pre-Delta vs Delta vs Omicron participants had increasing sore throat (40.9%, 54.6%, 70.6%; P <. 001), cough (50.9%, 63.3%, 66.7%; P <. 001), and runny noses (48.9%, 71.3%, 72.9%; P <. 001). We observed reductions during Omicron in chest pain (31.1%, 24.2%, 20.9%; P <. 001), shortness of breath (42.7%, 29.5%, 27.5%; P <. 001), loss of taste (47.1%, 61.8%, 19.2%; P <. 001), and loss of smell (47.5%, 55.6%, 20.0%; P <. 001). After adjustment, those infected during Omicron had significantly higher odds of sore throat vs pre-Delta (odds ratio [OR], 2.76; 95% CI, 2.26-3.35) and Delta (OR, 1.96; 95% CI, 1.69-2.28). Conclusions: Participants infected during Omicron were more likely to report symptoms of common respiratory viruses, such as sore throat, and less likely to report loss of smell and taste. Trial registration: NCT04610515.

Original language	English (US)
Article number	ofad275
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofad275
State	Published - Jul 1 2023

Keywords

COVID-19
COVID-19 symptoms
SARS-COV-2
variants of concern

ASJC Scopus subject areas

Oncology
Infectious Diseases

Access to Document

10.1093/ofid/ofad275

Cite this

Wang, R. C., Gottlieb, M., Montoy, J. C. C., Rodriguez, R. M., Yu, H., Spatz, E. S., Chandler, C. W., Elmore, J. G., Hannikainen, P. A., Chang, A. M., Hill, M., Huebinger, R. M., Idris, A. H., Koo, K., Li, S. X., McDonald, S., Nichol, G., O'Laughlin, K. N., Plumb, I. D., ... Briggs-Hagen, M. (2023). Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022. Open Forum Infectious Diseases, 10(7), Article ofad275. https://doi.org/10.1093/ofid/ofad275

Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022. / Wang, Ralph C.; Gottlieb, Michael; Montoy, Juan Carlos C. et al.
In: Open Forum Infectious Diseases, Vol. 10, No. 7, ofad275, 01.07.2023.

Research output: Contribution to journal › Article › peer-review

Wang, RC, Gottlieb, M, Montoy, JCC, Rodriguez, RM, Yu, H, Spatz, ES, Chandler, CW, Elmore, JG, Hannikainen, PA, Chang, AM, Hill, M, Huebinger, RM, Idris, AH, Koo, K, Li, SX, McDonald, S, Nichol, G, O'Laughlin, KN, Plumb, ID, Santangelo, M, Saydah, S, Stephens, KA, Venkatesh, AK, Weinstein, RA, Weinstein, RA, Santangelo, M, Koo, K, Derden, A, Gatling, K, Guzman, D, Yang, G, Kaadan, M, Hassaballa, M, Jerger, R, Ahmed, Z, Choi, M, Venkatesh, A, Spatz, E, Lin, Z, Li, SX, Yu, H, Liu, M, Venkatesh, A, Spatz, E, Ulrich, A, Kinsman, J, Dorney, J, Pierce, S, Puente, X, Nichol, G, Stephens, K, Anderson, J, Morse, D, Adams, K, Maat, Z, Stober, T, O'Laughlin, KN, Gentile, N, Geyer, RE, Willis, M, Ruiz, L, Malone, K, Park, J, Rising, K, Kean, E, Kelly, M, Schaeffer, K, Shughart, L, Shughart, H, Renzi, N, Amadio, G, Grau, D, Watts, P, Cheng, D, Miao, J, Shutty, C, Charlton, A, Hill, M, Site, RH, Chavez, S, Kane, A, Nikonowicz, P, Idris, AH, McDonald, S, Gallegos, D, Martin, R, Elmore, J, Wisk, L, L'Hommedieu, M, Chandler, C, Eguchi, M, Roldan, KD, Villegas, N, Moreno, R, Rodriguez, R, Wang, RC, Montoy, JC, Kemball, R, Chan, V, Chavez, CL, Wong, A, Arreguin, M, Plumb, ID, Hall, AJ, Saydah, S & Briggs-Hagen, M 2023, 'Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022', Open Forum Infectious Diseases, vol. 10, no. 7, ofad275. https://doi.org/10.1093/ofid/ofad275

@article{1040debbd684465eb950ae891c698d2f,

title = "Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022",

abstract = "Background: While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence of acute symptoms across pre-Delta, Delta, and Omicron. Methods: We conducted an analysis of the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. We determined the association between the pre-Delta, Delta, and Omicron time periods and the prevalence of 21 coronavirus disease 2019 (COVID-19) acute symptoms. Results: We enrolled 4113 participants from December 2020 to June 2022. Pre-Delta vs Delta vs Omicron participants had increasing sore throat (40.9%, 54.6%, 70.6%; P <. 001), cough (50.9%, 63.3%, 66.7%; P <. 001), and runny noses (48.9%, 71.3%, 72.9%; P <. 001). We observed reductions during Omicron in chest pain (31.1%, 24.2%, 20.9%; P <. 001), shortness of breath (42.7%, 29.5%, 27.5%; P <. 001), loss of taste (47.1%, 61.8%, 19.2%; P <. 001), and loss of smell (47.5%, 55.6%, 20.0%; P <. 001). After adjustment, those infected during Omicron had significantly higher odds of sore throat vs pre-Delta (odds ratio [OR], 2.76; 95% CI, 2.26-3.35) and Delta (OR, 1.96; 95% CI, 1.69-2.28). Conclusions: Participants infected during Omicron were more likely to report symptoms of common respiratory viruses, such as sore throat, and less likely to report loss of smell and taste. Trial registration: NCT04610515.",

keywords = "COVID-19, COVID-19 symptoms, SARS-COV-2, variants of concern",

author = "Wang, {Ralph C.} and Michael Gottlieb and Montoy, {Juan Carlos C.} and Rodriguez, {Robert M.} and Huihui Yu and Spatz, {Erica S.} and Chandler, {Christopher W.} and Elmore, {Joann G.} and Hannikainen, {Paavali A.} and Chang, {Anna Marie} and Mandy Hill and Huebinger, {Ryan M.} and Idris, {Ahamed H.} and Katherine Koo and Li, {Shu Xia} and Samuel McDonald and Graham Nichol and O'Laughlin, {Kelli N.} and Plumb, {Ian D.} and Michelle Santangelo and Sharon Saydah and Stephens, {Kari A.} and Venkatesh, {Arjun K.} and Weinstein, {Robert A.} and Weinstein, {Robert A.} and Michelle Santangelo and Katherine Koo and Antonia Derden and Kristyn Gatling and Diego Guzman and Geoffrey Yang and Marshall Kaadan and Minna Hassaballa and Ryan Jerger and Zohaib Ahmed and Michael Choi and Arjun Venkatesh and Erica Spatz and Zhenqiu Lin and Li, {Shu Xia} and Huihui Yu and Mengni Liu and Arjun Venkatesh and Erica Spatz and Andrew Ulrich and Jeremiah Kinsman and Jocelyn Dorney and Senyte Pierce and Xavier Puente and Graham Nichol and Kari Stephens and Jill Anderson and Dana Morse and Karen Adams and Zenoura Maat and Tracy Stober and O'Laughlin, {Kelli N.} and Nikki Gentile and Geyer, {Rachel E.} and Michael Willis and Luis Ruiz and Kerry Malone and Jasmine Park and Kristin Rising and Efrat Kean and Morgan Kelly and Kevin Schaeffer and Lindsey Shughart and Hailey Shughart and Nicole Renzi and Grace Amadio and Dylan Grau and Phillip Watts and David Cheng and Jessica Miao and Carly Shutty and Alex Charlton and Mandy Hill and Site, {Ryan Huebinger} and Summer Chavez and Arun Kane and Peter Nikonowicz and Idris, {Ahamed H.} and Samuel McDonald and David Gallegos and Riley Martin and Joann Elmore and Lauren Wisk and Michelle L'Hommedieu and Chris Chandler and Megan Eguchi and Roldan, {Kate Diaz} and Nicole Villegas and Raul Moreno and Robert Rodriguez and Wang, {Ralph C.} and Montoy, {Juan Carlos} and Robin Kemball and Virginia Chan and Chavez, {Cecilia Lara} and Angela Wong and Mireya Arreguin and Plumb, {Ian D.} and Hall, {Aron J.} and Sharon Saydah and Melissa Briggs-Hagen",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2023",

month = jul,

day = "1",

doi = "10.1093/ofid/ofad275",

language = "English (US)",

volume = "10",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms

T2 - Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022

AU - Wang, Ralph C.

AU - Gottlieb, Michael

AU - Montoy, Juan Carlos C.

AU - Rodriguez, Robert M.

AU - Yu, Huihui

AU - Spatz, Erica S.

AU - Chandler, Christopher W.

AU - Elmore, Joann G.

AU - Hannikainen, Paavali A.

AU - Chang, Anna Marie

AU - Hill, Mandy

AU - Huebinger, Ryan M.

AU - Idris, Ahamed H.

AU - Koo, Katherine

AU - Li, Shu Xia

AU - McDonald, Samuel

AU - Nichol, Graham

AU - O'Laughlin, Kelli N.

AU - Plumb, Ian D.

AU - Santangelo, Michelle

AU - Saydah, Sharon

AU - Stephens, Kari A.

AU - Venkatesh, Arjun K.

AU - Weinstein, Robert A.

AU - Santangelo, Michelle

AU - Koo, Katherine

AU - Derden, Antonia

AU - Gatling, Kristyn

AU - Guzman, Diego

AU - Yang, Geoffrey

AU - Kaadan, Marshall

AU - Hassaballa, Minna

AU - Jerger, Ryan

AU - Ahmed, Zohaib

AU - Choi, Michael

AU - Venkatesh, Arjun

AU - Spatz, Erica

AU - Lin, Zhenqiu

AU - Li, Shu Xia

AU - Yu, Huihui

AU - Liu, Mengni

AU - Venkatesh, Arjun

AU - Spatz, Erica

AU - Ulrich, Andrew

AU - Kinsman, Jeremiah

AU - Dorney, Jocelyn

AU - Pierce, Senyte

AU - Puente, Xavier

AU - Nichol, Graham

AU - Stephens, Kari

AU - Anderson, Jill

AU - Morse, Dana

AU - Adams, Karen

AU - Maat, Zenoura

AU - Stober, Tracy

AU - O'Laughlin, Kelli N.

AU - Gentile, Nikki

AU - Geyer, Rachel E.

AU - Willis, Michael

AU - Ruiz, Luis

AU - Malone, Kerry

AU - Park, Jasmine

AU - Rising, Kristin

AU - Kean, Efrat

AU - Kelly, Morgan

AU - Schaeffer, Kevin

AU - Shughart, Lindsey

AU - Shughart, Hailey

AU - Renzi, Nicole

AU - Amadio, Grace

AU - Grau, Dylan

AU - Watts, Phillip

AU - Cheng, David

AU - Miao, Jessica

AU - Shutty, Carly

AU - Charlton, Alex

AU - Hill, Mandy

AU - Site, Ryan Huebinger

AU - Chavez, Summer

AU - Kane, Arun

AU - Nikonowicz, Peter

AU - Idris, Ahamed H.

AU - McDonald, Samuel

AU - Gallegos, David

AU - Martin, Riley

AU - Elmore, Joann

AU - Wisk, Lauren

AU - L'Hommedieu, Michelle

AU - Chandler, Chris

AU - Eguchi, Megan

AU - Roldan, Kate Diaz

AU - Villegas, Nicole

AU - Moreno, Raul

AU - Rodriguez, Robert

AU - Wang, Ralph C.

AU - Montoy, Juan Carlos

AU - Kemball, Robin

AU - Chan, Virginia

AU - Chavez, Cecilia Lara

AU - Wong, Angela

AU - Arreguin, Mireya

AU - Plumb, Ian D.

AU - Hall, Aron J.

AU - Saydah, Sharon

AU - Briggs-Hagen, Melissa

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Background: While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence of acute symptoms across pre-Delta, Delta, and Omicron. Methods: We conducted an analysis of the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. We determined the association between the pre-Delta, Delta, and Omicron time periods and the prevalence of 21 coronavirus disease 2019 (COVID-19) acute symptoms. Results: We enrolled 4113 participants from December 2020 to June 2022. Pre-Delta vs Delta vs Omicron participants had increasing sore throat (40.9%, 54.6%, 70.6%; P <. 001), cough (50.9%, 63.3%, 66.7%; P <. 001), and runny noses (48.9%, 71.3%, 72.9%; P <. 001). We observed reductions during Omicron in chest pain (31.1%, 24.2%, 20.9%; P <. 001), shortness of breath (42.7%, 29.5%, 27.5%; P <. 001), loss of taste (47.1%, 61.8%, 19.2%; P <. 001), and loss of smell (47.5%, 55.6%, 20.0%; P <. 001). After adjustment, those infected during Omicron had significantly higher odds of sore throat vs pre-Delta (odds ratio [OR], 2.76; 95% CI, 2.26-3.35) and Delta (OR, 1.96; 95% CI, 1.69-2.28). Conclusions: Participants infected during Omicron were more likely to report symptoms of common respiratory viruses, such as sore throat, and less likely to report loss of smell and taste. Trial registration: NCT04610515.

AB - Background: While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence of acute symptoms across pre-Delta, Delta, and Omicron. Methods: We conducted an analysis of the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. We determined the association between the pre-Delta, Delta, and Omicron time periods and the prevalence of 21 coronavirus disease 2019 (COVID-19) acute symptoms. Results: We enrolled 4113 participants from December 2020 to June 2022. Pre-Delta vs Delta vs Omicron participants had increasing sore throat (40.9%, 54.6%, 70.6%; P <. 001), cough (50.9%, 63.3%, 66.7%; P <. 001), and runny noses (48.9%, 71.3%, 72.9%; P <. 001). We observed reductions during Omicron in chest pain (31.1%, 24.2%, 20.9%; P <. 001), shortness of breath (42.7%, 29.5%, 27.5%; P <. 001), loss of taste (47.1%, 61.8%, 19.2%; P <. 001), and loss of smell (47.5%, 55.6%, 20.0%; P <. 001). After adjustment, those infected during Omicron had significantly higher odds of sore throat vs pre-Delta (odds ratio [OR], 2.76; 95% CI, 2.26-3.35) and Delta (OR, 1.96; 95% CI, 1.69-2.28). Conclusions: Participants infected during Omicron were more likely to report symptoms of common respiratory viruses, such as sore throat, and less likely to report loss of smell and taste. Trial registration: NCT04610515.

KW - COVID-19

KW - COVID-19 symptoms

KW - SARS-COV-2

KW - variants of concern

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U2 - 10.1093/ofid/ofad275

DO - 10.1093/ofid/ofad275

M3 - Article

C2 - 37426947

AN - SCOPUS:85165506339

SN - 2328-8957

VL - 10

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 7

M1 - ofad275

ER -

Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study-December 20, 2020-June 20, 2022

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