Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers

Mona Arbab; Yu Hui Chen; Roy B. Tishler; Lauren Gunasti; Jason Glass; Jo Ann Fugazzotto; Joseph H. Killoran; Rosh Sethi; Eleni Rettig; Donald Annino; Laura Goguen; Ravindra Uppaluri; Carolyn Hsu; Elaine Burke; Glenn J. Hanna; Jochen Lorch; Robert I. Haddad; Danielle N. Margalit; Jonathan D. Schoenfeld

doi:10.1002/hed.27031

Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers

Mona Arbab, Yu Hui Chen, Roy B. Tishler, Lauren Gunasti, Jason Glass, Jo Ann Fugazzotto, Joseph H. Killoran, Rosh Sethi, Eleni Rettig, Donald Annino, Laura Goguen, Ravindra Uppaluri, Carolyn Hsu, Elaine Burke, Glenn J. Hanna, Jochen Lorch, Robert I. Haddad, Danielle N. Margalit, Jonathan D. Schoenfeld

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Associations between patient-reported outcomes and dose to organs at risk (OARs) may promote management and guide future investigations. Methods: We retrospectively evaluated PROs and OAR dose in head and neck (H&N) cancer. Results: In 169 patients, we identified weak associations between: “Difficulty swallowing/chewing” and increased mean RT dose to the oral cavity, larynx, pharyngeal constrictor muscles (PCM) and contralateral parotid; “choking/coughing” and larynx mean dose; “problems with mucus in mouth and throat” and oral cavity, contralateral parotid mean dose and parotid V30, contralateral submandibular gland and PCM mean dose; “difficulty with voice/speech” and oral cavity, contralateral parotid, contralateral submandibular gland and larynx mean dose; and “dry mouth” and ipsilateral submandibular gland, oral cavity and PCM mean dose. Conclusion: We identified weak associations between PRO and dose to OARs—these data can guide on treatment management, patient counseling, and serve as a baseline for future investigations.

Original language	English (US)
Pages (from-to)	1442-1452
Number of pages	11
Journal	Head and Neck
Volume	44
Issue number	6
DOIs	https://doi.org/10.1002/hed.27031
State	Published - Jun 2022
Externally published	Yes

Keywords

head and neck cancers
organs at risk
patient reported outcome
radiation dose

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.27031

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Arbab, M., Chen, Y. H., Tishler, R. B., Gunasti, L., Glass, J., Fugazzotto, J. A., Killoran, J. H., Sethi, R., Rettig, E., Annino, D., Goguen, L., Uppaluri, R., Hsu, C., Burke, E., Hanna, G. J., Lorch, J., Haddad, R. I., Margalit, D. N., & Schoenfeld, J. D. (2022). Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers. Head and Neck, 44(6), 1442-1452. https://doi.org/10.1002/hed.27031

Arbab, M, Chen, YH, Tishler, RB, Gunasti, L, Glass, J, Fugazzotto, JA, Killoran, JH, Sethi, R, Rettig, E, Annino, D, Goguen, L, Uppaluri, R, Hsu, C, Burke, E, Hanna, GJ, Lorch, J, Haddad, RI, Margalit, DN & Schoenfeld, JD 2022, 'Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers', Head and Neck, vol. 44, no. 6, pp. 1442-1452. https://doi.org/10.1002/hed.27031

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abstract = "Background: Associations between patient-reported outcomes and dose to organs at risk (OARs) may promote management and guide future investigations. Methods: We retrospectively evaluated PROs and OAR dose in head and neck (H&N) cancer. Results: In 169 patients, we identified weak associations between: “Difficulty swallowing/chewing” and increased mean RT dose to the oral cavity, larynx, pharyngeal constrictor muscles (PCM) and contralateral parotid; “choking/coughing” and larynx mean dose; “problems with mucus in mouth and throat” and oral cavity, contralateral parotid mean dose and parotid V30, contralateral submandibular gland and PCM mean dose; “difficulty with voice/speech” and oral cavity, contralateral parotid, contralateral submandibular gland and larynx mean dose; and “dry mouth” and ipsilateral submandibular gland, oral cavity and PCM mean dose. Conclusion: We identified weak associations between PRO and dose to OARs—these data can guide on treatment management, patient counseling, and serve as a baseline for future investigations.",

keywords = "head and neck cancers, organs at risk, patient reported outcome, radiation dose",

author = "Mona Arbab and Chen, {Yu Hui} and Tishler, {Roy B.} and Lauren Gunasti and Jason Glass and Fugazzotto, {Jo Ann} and Killoran, {Joseph H.} and Rosh Sethi and Eleni Rettig and Donald Annino and Laura Goguen and Ravindra Uppaluri and Carolyn Hsu and Elaine Burke and Hanna, {Glenn J.} and Jochen Lorch and Haddad, {Robert I.} and Margalit, {Danielle N.} and Schoenfeld, {Jonathan D.}",

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doi = "10.1002/hed.27031",

language = "English (US)",

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AU - Arbab, Mona

AU - Chen, Yu Hui

AU - Tishler, Roy B.

AU - Gunasti, Lauren

AU - Glass, Jason

AU - Fugazzotto, Jo Ann

AU - Killoran, Joseph H.

AU - Sethi, Rosh

AU - Rettig, Eleni

AU - Annino, Donald

AU - Goguen, Laura

AU - Uppaluri, Ravindra

AU - Hsu, Carolyn

AU - Burke, Elaine

AU - Hanna, Glenn J.

AU - Lorch, Jochen

AU - Haddad, Robert I.

AU - Margalit, Danielle N.

AU - Schoenfeld, Jonathan D.

PY - 2022/6

Y1 - 2022/6

N2 - Background: Associations between patient-reported outcomes and dose to organs at risk (OARs) may promote management and guide future investigations. Methods: We retrospectively evaluated PROs and OAR dose in head and neck (H&N) cancer. Results: In 169 patients, we identified weak associations between: “Difficulty swallowing/chewing” and increased mean RT dose to the oral cavity, larynx, pharyngeal constrictor muscles (PCM) and contralateral parotid; “choking/coughing” and larynx mean dose; “problems with mucus in mouth and throat” and oral cavity, contralateral parotid mean dose and parotid V30, contralateral submandibular gland and PCM mean dose; “difficulty with voice/speech” and oral cavity, contralateral parotid, contralateral submandibular gland and larynx mean dose; and “dry mouth” and ipsilateral submandibular gland, oral cavity and PCM mean dose. Conclusion: We identified weak associations between PRO and dose to OARs—these data can guide on treatment management, patient counseling, and serve as a baseline for future investigations.

AB - Background: Associations between patient-reported outcomes and dose to organs at risk (OARs) may promote management and guide future investigations. Methods: We retrospectively evaluated PROs and OAR dose in head and neck (H&N) cancer. Results: In 169 patients, we identified weak associations between: “Difficulty swallowing/chewing” and increased mean RT dose to the oral cavity, larynx, pharyngeal constrictor muscles (PCM) and contralateral parotid; “choking/coughing” and larynx mean dose; “problems with mucus in mouth and throat” and oral cavity, contralateral parotid mean dose and parotid V30, contralateral submandibular gland and PCM mean dose; “difficulty with voice/speech” and oral cavity, contralateral parotid, contralateral submandibular gland and larynx mean dose; and “dry mouth” and ipsilateral submandibular gland, oral cavity and PCM mean dose. Conclusion: We identified weak associations between PRO and dose to OARs—these data can guide on treatment management, patient counseling, and serve as a baseline for future investigations.

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Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers

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