Association between A49T polymorphism of SRD5A2 gene and risk of prostate cancer

Ming Tong, Jun Kui Al, Yi Ming Yuan, Yi Yin, Li Qun Zhou, Dian Qi Xin, Ming Li, Yan Qun Na

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To investigate the association between A49T polymorpbism of SRD5A2 gene and risk of prostate cancer. Methods: PCR was used to examine the A49T polymorphisms of SRD5A2 gene in the tissues of prostate cancer resected from 112 patients (CaP group) and the specimens of benign prostate hyperplasia (BPH group) resected from 89 patients. The association of A49T polymorphism with age of onset, FPSA, TPSA, F/T, T stage, and Gleason score were analyzed. Results: There was no significant difference in A49T polymorphism between the CaP and BPH groups (P > 0.05). The average age of CaP patients was significantly higher than that of the BPH patients (P < 0.05). In the CaP patients, the Gleason score was significantly higher, and the age of onset was significantly lower in the AT + TT genotype than in the AA genotype (both P < 0.05)2. The age of onset of the AA + AT group was significantly lower than that of the AA group (P < 0.05). Conclusion: AA + AT genotype may be of worse prognosis, however, without significant difference. Rank scoring may reflect the relation between Gleason score and A49T genotype and estimate the prognosis better than two-level discrete evaluation.

Original languageEnglish (US)
Pages (from-to)1319-1321
Number of pages3
JournalNational Medical Journal of China
Issue number19
StatePublished - May 25 2005


  • Gene polymorphism
  • Prostate carcinoma
  • SRD5A2 gene

ASJC Scopus subject areas

  • Medicine(all)


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