Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

Rozalyn L. Rodwin; Natalie J. DelRocco; Emily Hibbitts; Meenakshi Devidas; Moira K. Whitley; Caroline E. Mohrmann; Reuven J. Schore; Elizabeth Raetz; Naomi J. Winick; Stephen P. Hunger; Mignon L. Loh; Marilyn J. Hockenberry; Xiaomei Ma; Anne L. Angiolillo; Kirsten K. Ness; John A. Kairalla; Nina S. Kadan-Lottick

doi:10.1002/pbc.30634

Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

Rozalyn L. Rodwin, Natalie J. DelRocco, Emily Hibbitts, Meenakshi Devidas, Moira K. Whitley, Caroline E. Mohrmann, Reuven J. Schore, Elizabeth Raetz, Naomi J. Winick, Stephen P. Hunger, Mignon L. Loh, Marilyn J. Hockenberry, Xiaomei Ma, Anne L. Angiolillo, Kirsten K. Ness, John A. Kairalla, Nina S. Kadan-Lottick

Research output: Contribution to journal › Article › peer-review

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

Original language	English (US)
Article number	e30634
Journal	Pediatric Blood and Cancer
Volume	70
Issue number	11
DOIs	https://doi.org/10.1002/pbc.30634
State	Published - Nov 2023

Keywords

chemotherapy-induced peripheral neuropathy
motor neuropathy
pediatric acute lymphoblastic leukemia
proxy-reported surveys
sensory neuropathy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.30634

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Rodwin, R. L., DelRocco, N. J., Hibbitts, E., Devidas, M., Whitley, M. K., Mohrmann, C. E., Schore, R. J., Raetz, E., Winick, N. J., Hunger, S. P., Loh, M. L., Hockenberry, M. J., Ma, X., Angiolillo, A. L., Ness, K. K., Kairalla, J. A., & Kadan-Lottick, N. S. (2023). Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia. Pediatric Blood and Cancer, 70(11), Article e30634. https://doi.org/10.1002/pbc.30634

Rodwin, RL, DelRocco, NJ, Hibbitts, E, Devidas, M, Whitley, MK, Mohrmann, CE, Schore, RJ, Raetz, E, Winick, NJ, Hunger, SP, Loh, ML, Hockenberry, MJ, Ma, X, Angiolillo, AL, Ness, KK, Kairalla, JA & Kadan-Lottick, NS 2023, 'Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia', Pediatric Blood and Cancer, vol. 70, no. 11, e30634. https://doi.org/10.1002/pbc.30634

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title = "Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia",

abstract = "Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.",

keywords = "chemotherapy-induced peripheral neuropathy, motor neuropathy, pediatric acute lymphoblastic leukemia, proxy-reported surveys, sensory neuropathy",

author = "Rodwin, {Rozalyn L.} and DelRocco, {Natalie J.} and Emily Hibbitts and Meenakshi Devidas and Whitley, {Moira K.} and Mohrmann, {Caroline E.} and Schore, {Reuven J.} and Elizabeth Raetz and Winick, {Naomi J.} and Hunger, {Stephen P.} and Loh, {Mignon L.} and Hockenberry, {Marilyn J.} and Xiaomei Ma and Angiolillo, {Anne L.} and Ness, {Kirsten K.} and Kairalla, {John A.} and Kadan-Lottick, {Nina S.}",

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year = "2023",

month = nov,

doi = "10.1002/pbc.30634",

language = "English (US)",

volume = "70",

journal = "Pediatric Blood and Cancer",

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AU - Rodwin, Rozalyn L.

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AU - Hibbitts, Emily

AU - Devidas, Meenakshi

AU - Whitley, Moira K.

AU - Mohrmann, Caroline E.

AU - Schore, Reuven J.

AU - Raetz, Elizabeth

AU - Winick, Naomi J.

AU - Hunger, Stephen P.

AU - Loh, Mignon L.

AU - Hockenberry, Marilyn J.

AU - Ma, Xiaomei

AU - Angiolillo, Anne L.

AU - Ness, Kirsten K.

AU - Kairalla, John A.

AU - Kadan-Lottick, Nina S.

PY - 2023/11

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N2 - Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

AB - Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64–0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54–0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

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KW - pediatric acute lymphoblastic leukemia

KW - proxy-reported surveys

KW - sensory neuropathy

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Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

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