TY - JOUR
T1 - Assessment of posterior fossa structures with midsagittal MRI
T2 - The effects of age
AU - Shah, Sunjay A.
AU - Doraiswamy, P. Murali
AU - Husain, Mustafa M.
AU - Figiel, Gary S.
AU - Boyko, Orest B.
AU - McDonald, William M.
AU - Ellinwood, Everett H.
AU - Ranga Rama Krishnan, K.
N1 - Funding Information:
ACKNOWLEIX;EMENTS The authors wish to thank Mr. Robert A. Burn, RT and MRI staff for expert technical assistance. This research was supported by grants NIMH MH-44716, MH-42210, and by a research stipend through the UNC-CH School of Medicine.
PY - 1991
Y1 - 1991
N2 - Midsagittal magnetic resonance (MR) images of 36 normal volunteers, ranging in age from 26 to 79 years, were used to evaluate the effects of age on the size of posterior fossa structures (cerebellar vermis, midbrain, pons, medulla and fourth ventricle). Our results demonstrate a highly statistically significant age-related decline in the cross-sectional area of the midbrain (r = -.44, p<0.007), a less prominent decline in the area of the anterior cerebellar vermis (r = -.33, p<0.05) and striking intercorrelations between the dimensions of the pons, medulla and cerebellar vermis. To the best of our knowledge, this is the first MRI demonstration of midbrain atrophy during aging in normal adults.
AB - Midsagittal magnetic resonance (MR) images of 36 normal volunteers, ranging in age from 26 to 79 years, were used to evaluate the effects of age on the size of posterior fossa structures (cerebellar vermis, midbrain, pons, medulla and fourth ventricle). Our results demonstrate a highly statistically significant age-related decline in the cross-sectional area of the midbrain (r = -.44, p<0.007), a less prominent decline in the area of the anterior cerebellar vermis (r = -.33, p<0.05) and striking intercorrelations between the dimensions of the pons, medulla and cerebellar vermis. To the best of our knowledge, this is the first MRI demonstration of midbrain atrophy during aging in normal adults.
KW - Cerebellar vermis
KW - Fourth ventricle
KW - Magnetic resonance
KW - Medulla
KW - Midbrain
KW - Pons
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U2 - 10.1016/0197-4580(91)90025-F
DO - 10.1016/0197-4580(91)90025-F
M3 - Article
C2 - 1961373
AN - SCOPUS:0025816546
SN - 0197-4580
VL - 12
SP - 371
EP - 374
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 4
ER -