Assessment of posterior fossa structures with midsagittal MRI: The effects of age

Sunjay A. Shah, P. Murali Doraiswamy, Mustafa M. Husain, Gary S. Figiel, Orest B. Boyko, William M. McDonald, Everett H. Ellinwood, K. Ranga Rama Krishnan

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Midsagittal magnetic resonance (MR) images of 36 normal volunteers, ranging in age from 26 to 79 years, were used to evaluate the effects of age on the size of posterior fossa structures (cerebellar vermis, midbrain, pons, medulla and fourth ventricle). Our results demonstrate a highly statistically significant age-related decline in the cross-sectional area of the midbrain (r = -.44, p<0.007), a less prominent decline in the area of the anterior cerebellar vermis (r = -.33, p<0.05) and striking intercorrelations between the dimensions of the pons, medulla and cerebellar vermis. To the best of our knowledge, this is the first MRI demonstration of midbrain atrophy during aging in normal adults.

Original languageEnglish (US)
Pages (from-to)371-374
Number of pages4
JournalNeurobiology of Aging
Issue number4
StatePublished - 1991


  • Cerebellar vermis
  • Fourth ventricle
  • Magnetic resonance
  • Medulla
  • Midbrain
  • Pons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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