Assessment of exhaled nitric oxide kinetics in healthy infants

T. Martínez, A. Weist, T. Williams, C. Clem, P. Silkoff, R. S. Tepper

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Exhaled nitric oxide (FENO) measurements provide a noninvasive approach to the evaluation of airway inflammation. Flow-independent NO exchange parameters [airway NO transfer factor (DNO) and airway wall NO concentration (CwNO)] can be estimated from FENO measurements at low flows and may elucidate mechanisms of disturbances in NO exchange. We measured FENO in sedated infants by using an adaptation of a raised lung volume rapid thoracic compression technique that creates forced expiration through a mass-flow controller that lasts 5-10 s, at a constant preset flow. We measured FENO at expired flows of 50, 25, and 15 ml/s in five healthy infants (7-31 mo). Median FENO increased [24, 40, and 60 parts per billion (ppb)] with decreasing expiratory flows (50, 25, and 15 ml/s). Group median (range) for DNO and CwNO were 12.7 (3.2-37) × 10-3 nl·s-1·ppb-1 and 108.9 (49-385) ppb, respectively, similar to values reported in healthy adults. Exhaled NO is flow dependent; flow-independent parameters of exhaled NO kinetics can be assessed in infants and are similar to values described in adults.

Original languageEnglish (US)
Pages (from-to)2384-2390
Number of pages7
JournalJournal of applied physiology
Issue number6
StatePublished - Jun 1 2003


  • Airway inflammation
  • Lung function
  • Nitric oxide measurement

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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