Assessing risks for gastric cancer: New tools for pathologists

Robert M. Genta, Massimo Rugge

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians' approach to the management of patients with gastric conditions.

Original languageEnglish (US)
Pages (from-to)5622-5627
Number of pages6
JournalWorld Journal of Gastroenterology
Issue number35
StatePublished - Sep 21 2006


  • Gastritis
  • Gastritis histology
  • Staging and grading

ASJC Scopus subject areas

  • Gastroenterology


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