Assessing residual motion for gated proton-beam radiotherapy

Gregory C. Sharp, Hsiao Ming Lu, Alexei Trofimov, Xiaoli Tang, Steve B. Jiang, Julie Turcotte, David P. Gierga, George T Y Chen, Theodore S. Hong

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Gated radiation therapy is a promising method for improving the dose conformality of treatments to moving targets and reducing the total volume of irradiated tissue. Target motion is of particular concern in proton beam radiotherapy, due to the finite range of proton dose deposition in tissue. Gating allows one to reduce the extent of variation, due to respiration, of the radiological depth to target during treatment delivery. However, respiratory surrogates typically used for gating do not always accurately reflect the position of the internal target. For instance, a phase delay often exists between the internal motion and the motion of the surrogate. Another phenomenon, baseline drifting refers to a gradual change in the exhale position over time, which generally affects the external and internal markers differently. This study examines the influence of these two physiological phenomena on gated radiotherapy using an external surrogate.

Original languageEnglish (US)
Pages (from-to)A55-A59
JournalJournal of radiation research
Issue numberSUPPL. A
StatePublished - 2007


  • Liver cancer
  • Organ motion
  • Proton radiotherapy

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Assessing residual motion for gated proton-beam radiotherapy'. Together they form a unique fingerprint.

Cite this