Arteriovenous malformation animal model for radiosurgery: The rete mirabile

Antonio A F De Salles, Timothy D. Solberg, Paul Mischel, Tarik F. Massoud, Andres Plasencia, Steven Goetsch, Evandro De Souza, Fernando Viñuela

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


PURPOSE: To study the effects of single-dose radiation on the porcine rete mirabile, a tangle of microvessels that mimics human arteriovenous malformations of the brain. METHODS: Eight retia mirabilia received a single dose of radiation under stereotactic location with digital angiography and CT. The following doses were applied: 20, 30, 40, 50, 60, 70, 80, and 90 Gy. The animals were followed up for a period of 7 months. Findings at neurologic examination, serial angiography, and histopathologic examination were analyzed. RESULTS: Progressive occlusion as observed by angiography corresponded to the histopathologic finding of intimal hyperplasia; that is, marked thickening of the vessel wall, progressing to occlusion of the vascular lumen, and associated thrombosis. A direct dose response was noted for these changes. Neurologic findings were related to the dose distribution and to histologic findings in structures adjacent to the fete mirabile. CONCLUSION: The rete mirabile is an excellent model by which to study the radiologic and histologic effects of single-dose radiation to the microvasculature of the central nervous system.

Original languageEnglish (US)
Pages (from-to)1451-1458
Number of pages8
JournalAmerican Journal of Neuroradiology
Issue number8
StatePublished - Sep 1 1996


  • Animal studies
  • Arteriovenous malformations, cerebral
  • Radiation, effects

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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