Argonaute and TNRC6, partners in RNAi

Samantha T. Johnson, Krystal C. Johnson, David R. Corey

Research output: Chapter in Book/Report/Conference proceedingChapter


The control of gene expression by RNA interference (RNAi) requires that small RNAs selectively recognize sequences within the transcriptome. Complementary hybridization between the guide strand of small duplex RNAs and their targets is necessary for recognition. Proteins make a critical contribution to target recognition by protecting small RNAs from degradation by enzymes, facilitating efficient recognition, and enhancing discrimination between target sequences and closely related “off-target” sequences. Here, we focus on the Argonaute (AGO) protein family, the factor that binds directly to small RNAs, and the Trinucleotide repeat-containing protein six (TNRC6) family, scaffolding proteins that help organize gene silencing.

Original languageEnglish (US)
Title of host publicationRNA Therapeutics
Subtitle of host publicationThe Evolving Landscape of RNA Therapeutics
Number of pages20
ISBN (Electronic)9780128215951
ISBN (Print)9780128217399
StatePublished - Jan 1 2022
Externally publishedYes


  • AGO protein
  • Cytoplasmic nuclear separation
  • eCLIP
  • Enzyme
  • Immunoprecipitation
  • RNA interference
  • TNRC6 protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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