Applications and limitations of perfusion-dependent functional brain mapping for neurosurgical guidance.

Nader Pouratian, Sameer Sheth, Susan Y. Bookheimer, Neil A. Martin, Arthur W. Toga

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Perfusion-dependent brain mapping modalities, such as functional magnetic resonance imaging, positron emission tomography, and optical imaging of intrinsic signals, have become increasingly popular for neurosurgical guidance because they offer a relatively rapid and noninvasive means of mapping brain function. These modalities are unique because they rely on perfusion-related signals that are coupled with neuronal activity to map the brain instead of measuring electrophysiological responses. They consequently present unique challenges to the clinician in terms of understanding the significance and limitations of the maps they produce. In particular, one must be aware of limitations of the modalities with respect to spatial specificity, sensitivity, and reliability of these maps and how the presence of intracranial lesions may further complicate these issues. The authors review the evolution, interpretation, and limitations of perfusion-based brain mapping techniques, with special attention to clinical implications of the brain maps.

Original languageEnglish (US)
Pages (from-to)E2
JournalNeurosurgical focus
Issue number1
StatePublished - Jul 15 2003
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Applications and limitations of perfusion-dependent functional brain mapping for neurosurgical guidance.'. Together they form a unique fingerprint.

Cite this