Application of genetic algorithm to the QSAR research of pyrrolobenzothiazepinones and pyrrolobenzoxazepinones-novel and specific non-nucleoside HIV-1 reverse transcription inhibitors

Ting Jun Hou; Jun Mei Wang; You Yong Li; Xiao Jie Xu

Application of genetic algorithm to the QSAR research of pyrrolobenzothiazepinones and pyrrolobenzoxazepinones-novel and specific non-nucleoside HIV-1 reverse transcription inhibitors

Ting Jun Hou, Jun Mei Wang, You Yong Li, Xiao Jie Xu

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic Algorithm (GA) was used to study the quantitative structural parameters and activity relationship of pyrrolobenzothizepinones and pyrrolobenzoxazepinones's inhibitory activities with non-nucleoside HIV-1 reverse transcriptase (RT). A group of linear polynomial models with good relationship have been built to get some useful information that other methods can not offer.

Original language	English (US)
Pages (from-to)	651-654
Number of pages	4
Journal	Chinese Chemical Letters
Volume	9
Issue number	7
State	Published - 1998

Keywords

GA(genetic algorithm)
HIV
QSAR

ASJC Scopus subject areas

General Chemistry

Cite this

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title = "Application of genetic algorithm to the QSAR research of pyrrolobenzothiazepinones and pyrrolobenzoxazepinones-novel and specific non-nucleoside HIV-1 reverse transcription inhibitors",

abstract = "Genetic Algorithm (GA) was used to study the quantitative structural parameters and activity relationship of pyrrolobenzothizepinones and pyrrolobenzoxazepinones's inhibitory activities with non-nucleoside HIV-1 reverse transcriptase (RT). A group of linear polynomial models with good relationship have been built to get some useful information that other methods can not offer.",

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author = "Hou, {Ting Jun} and Wang, {Jun Mei} and Li, {You Yong} and Xu, {Xiao Jie}",

year = "1998",

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pages = "651--654",

journal = "Chinese Chemical Letters",

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AU - Hou, Ting Jun

AU - Wang, Jun Mei

AU - Li, You Yong

AU - Xu, Xiao Jie

PY - 1998

Y1 - 1998

N2 - Genetic Algorithm (GA) was used to study the quantitative structural parameters and activity relationship of pyrrolobenzothizepinones and pyrrolobenzoxazepinones's inhibitory activities with non-nucleoside HIV-1 reverse transcriptase (RT). A group of linear polynomial models with good relationship have been built to get some useful information that other methods can not offer.

AB - Genetic Algorithm (GA) was used to study the quantitative structural parameters and activity relationship of pyrrolobenzothizepinones and pyrrolobenzoxazepinones's inhibitory activities with non-nucleoside HIV-1 reverse transcriptase (RT). A group of linear polynomial models with good relationship have been built to get some useful information that other methods can not offer.

KW - GA(genetic algorithm)

KW - HIV

KW - QSAR

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M3 - Article

AN - SCOPUS:0032237924

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Application of genetic algorithm to the QSAR research of pyrrolobenzothiazepinones and pyrrolobenzoxazepinones-novel and specific non-nucleoside HIV-1 reverse transcription inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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