Apoptotic colopathy: A pragmatic approach to diagnosis

Dipti M. Karamchandani, Runjan Chetty Review

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


'Apoptotic colopathy' is an umbrella term signifying a pattern of injury where the gastrointestinal biopsy shows a colitic picture with apoptosis as the predominant histological feature. Although the entities within apoptotic colopathy share a common histological feature- 'apoptosis', there is a list of varied clinical differential diagnoses that produce this similar histological pattern of injury. These include graft-versus-host disease, druginduced injury due to multiple drugs (in particular, mycophenolate mofetil, check point inhibitor therapy and some others), infections (particularly cytomegalovirus, adenovirus and some others), immune disorders and other miscellaneous causes. However, the management of these varied differentials is strikingly different, thus necessitating an algorithmic approach for accurate diagnosis and optimal patient management. A definitive diagnosis requires interpretation of varied histological findings in the appropriate clinical context including clinical history, drug history and laboratory findings. This review will focus on the histopathological findings of varied entities that can manifest as 'apoptotic colopathy' on assessment of colonic biopsies.

Original languageEnglish (US)
Pages (from-to)1033-1040
Number of pages8
JournalJournal of clinical pathology
Issue number12
StatePublished - Dec 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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