TY - JOUR
T1 - Apoptotic colopathy
T2 - A pragmatic approach to diagnosis
AU - Karamchandani, Dipti M.
AU - Review, Runjan Chetty
N1 - Publisher Copyright:
© Author(s) (or theiremployer(s)) 2018. Nocommercial re-use. See rights and permissions. Published by BMJ.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - 'Apoptotic colopathy' is an umbrella term signifying a pattern of injury where the gastrointestinal biopsy shows a colitic picture with apoptosis as the predominant histological feature. Although the entities within apoptotic colopathy share a common histological feature- 'apoptosis', there is a list of varied clinical differential diagnoses that produce this similar histological pattern of injury. These include graft-versus-host disease, druginduced injury due to multiple drugs (in particular, mycophenolate mofetil, check point inhibitor therapy and some others), infections (particularly cytomegalovirus, adenovirus and some others), immune disorders and other miscellaneous causes. However, the management of these varied differentials is strikingly different, thus necessitating an algorithmic approach for accurate diagnosis and optimal patient management. A definitive diagnosis requires interpretation of varied histological findings in the appropriate clinical context including clinical history, drug history and laboratory findings. This review will focus on the histopathological findings of varied entities that can manifest as 'apoptotic colopathy' on assessment of colonic biopsies.
AB - 'Apoptotic colopathy' is an umbrella term signifying a pattern of injury where the gastrointestinal biopsy shows a colitic picture with apoptosis as the predominant histological feature. Although the entities within apoptotic colopathy share a common histological feature- 'apoptosis', there is a list of varied clinical differential diagnoses that produce this similar histological pattern of injury. These include graft-versus-host disease, druginduced injury due to multiple drugs (in particular, mycophenolate mofetil, check point inhibitor therapy and some others), infections (particularly cytomegalovirus, adenovirus and some others), immune disorders and other miscellaneous causes. However, the management of these varied differentials is strikingly different, thus necessitating an algorithmic approach for accurate diagnosis and optimal patient management. A definitive diagnosis requires interpretation of varied histological findings in the appropriate clinical context including clinical history, drug history and laboratory findings. This review will focus on the histopathological findings of varied entities that can manifest as 'apoptotic colopathy' on assessment of colonic biopsies.
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U2 - 10.1136/jclinpath-2018-205388
DO - 10.1136/jclinpath-2018-205388
M3 - Review article
C2 - 30275102
AN - SCOPUS:85054340058
SN - 0021-9746
VL - 71
SP - 1033
EP - 1040
JO - Journal of clinical pathology
JF - Journal of clinical pathology
IS - 12
ER -