TY - JOUR
T1 - Apolipoproteins in human cerebrospinal fluid
AU - Roheim, P. S.
AU - Carey, M.
AU - Forte, T.
AU - Vega, G. L.
PY - 1979
Y1 - 1979
N2 - The presence of apolipoproteins A-I, E, C-II, and C-III and the absence of apolipoprotein B was demonstrated in human cerebrospinal fluid. The concentration of apolipoproteins was measured by electroimmunoassay. Apolipoprotein E, C-II, and C-III were present in cerebrospinal fluid at 3-5% of their concentration in plasma; the cerebrospinal fluid level of apolipoprotein A-I was 0,4%. Most of the cerebrospinal fluid apolipoproteins were present in the p<1.21 g/ml lipoprotein fraction. The major apolipoproteins of cerebrospinal fluid are E and A-I. The possible mechanism of transfer and the physiological and pathophysiological role of apolipoproteins in cerebrospinal fluid are postulated.
AB - The presence of apolipoproteins A-I, E, C-II, and C-III and the absence of apolipoprotein B was demonstrated in human cerebrospinal fluid. The concentration of apolipoproteins was measured by electroimmunoassay. Apolipoprotein E, C-II, and C-III were present in cerebrospinal fluid at 3-5% of their concentration in plasma; the cerebrospinal fluid level of apolipoprotein A-I was 0,4%. Most of the cerebrospinal fluid apolipoproteins were present in the p<1.21 g/ml lipoprotein fraction. The major apolipoproteins of cerebrospinal fluid are E and A-I. The possible mechanism of transfer and the physiological and pathophysiological role of apolipoproteins in cerebrospinal fluid are postulated.
UR - http://www.scopus.com/inward/record.url?scp=0345489156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345489156&partnerID=8YFLogxK
U2 - 10.1073/pnas.76.9.4646
DO - 10.1073/pnas.76.9.4646
M3 - Article
C2 - 291993
AN - SCOPUS:0345489156
SN - 0027-8424
VL - 76
SP - 4646
EP - 4649
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 9
ER -