Apolipoprotein e receptor 2 and very-low-density lipoprotein receptor: An overview

Hans H. Bock, Joachim Herz

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


It is now well established that members of the low-density lipoprotein (LDL) receptor gene family are crucial regulators of different aspects of neuronal development, synaptic plasticity, maintenance of neuronal homeostasis, and neurodegeneration. This was highlighted in particular by the discovery that the lipoprotein receptors apolipoprotein E receptor-2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR) function as receptors for the neuronal signaling protein Reelin. In this chapter, we will briefly introduce the family of LDL receptor-related proteins and review the functions of its members ApoER2 and VLDLR as Reelin receptors and their role in the developing and adult brain.

Original languageEnglish (US)
Title of host publicationReelin Glycoprotein
Subtitle of host publicationStructure, Biology and Roles in Health and Disease
PublisherSpringer New York
Number of pages21
ISBN (Electronic)9780387767611
ISBN (Print)9780387767604
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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