APOE genotype modifies the association between central arterial stiffening and cognition in older adults

Francis E. Cambronero; Dandan Liu; Jacquelyn E. Neal; Elizabeth E. Moore; Katherine A. Gifford; James G. Terry; Sangeeta Nair; Kimberly R. Pechman; Katie E. Osborn; Timothy J. Hohman; Susan P. Bell; J. David Sweatt; Thomas J. Wang; Joshua A. Beckman; John Jeffrey Carr; Angela L. Jefferson

doi:10.1016/j.neurobiolaging.2018.02.009

APOE genotype modifies the association between central arterial stiffening and cognition in older adults

Francis E. Cambronero, Dandan Liu, Jacquelyn E. Neal, Elizabeth E. Moore, Katherine A. Gifford, James G. Terry, Sangeeta Nair, Kimberly R. Pechman, Katie E. Osborn, Timothy J. Hohman, Susan P. Bell, J. David Sweatt, Thomas J. Wang, Joshua A. Beckman, John Jeffrey Carr, Angela L. Jefferson

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 ± 7 years, 29% APOE-ε4 carrier) and mild cognitive impairment (n = 121, 73 ± 8 years, 42% APOE-ε4 carrier) completed neuropsychological assessment and cardiac MRI to assess aortic stiffening using pulse wave velocity (PWV, m/s). Linear regression models stratified by cognitive diagnosis related aortic PWV × APOE-ε4 status to neuropsychological performances, adjusting for demographic and vascular risk factors. PWV × APOE-ε4 related to poorer performance on measures of lexical retrieval (β = −0.29, p = 0.01), executive function (β = −0.44, p = 0.02), and episodic memory (β = −3.07, p = 0.02). Among participants with higher aortic PWV, APOE-ε4 modified the association between central arterial stiffening and cognition, such that carriers had worse performances than noncarriers. Findings add to a growing body of evidence for APOE-vascular interactions on cognition in older adults and warrant further research into less heart-healthy cohorts where the association between PWV and cognition among older adults might be stronger.

Original language	English (US)
Pages (from-to)	120-127
Number of pages	8
Journal	Neurobiology of Aging
Volume	67
DOIs	https://doi.org/10.1016/j.neurobiolaging.2018.02.009
State	Published - Jul 2018
Externally published	Yes

Keywords

Aging
Alzheimer's disease
Cardiac MRI
Mild cognitive impairment
Pulse wave velocity
Vascular risk factors

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2018.02.009

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Cambronero, F. E., Liu, D., Neal, J. E., Moore, E. E., Gifford, K. A., Terry, J. G., Nair, S., Pechman, K. R., Osborn, K. E., Hohman, T. J., Bell, S. P., Sweatt, J. D., Wang, T. J., Beckman, J. A., Carr, J. J., & Jefferson, A. L. (2018). APOE genotype modifies the association between central arterial stiffening and cognition in older adults. Neurobiology of Aging, 67, 120-127. https://doi.org/10.1016/j.neurobiolaging.2018.02.009

Cambronero, FE, Liu, D, Neal, JE, Moore, EE, Gifford, KA, Terry, JG, Nair, S, Pechman, KR, Osborn, KE, Hohman, TJ, Bell, SP, Sweatt, JD, Wang, TJ , Beckman, JA, Carr, JJ & Jefferson, AL 2018, 'APOE genotype modifies the association between central arterial stiffening and cognition in older adults', Neurobiology of Aging, vol. 67, pp. 120-127. https://doi.org/10.1016/j.neurobiolaging.2018.02.009

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title = "APOE genotype modifies the association between central arterial stiffening and cognition in older adults",

abstract = "Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 ± 7 years, 29% APOE-ε4 carrier) and mild cognitive impairment (n = 121, 73 ± 8 years, 42% APOE-ε4 carrier) completed neuropsychological assessment and cardiac MRI to assess aortic stiffening using pulse wave velocity (PWV, m/s). Linear regression models stratified by cognitive diagnosis related aortic PWV × APOE-ε4 status to neuropsychological performances, adjusting for demographic and vascular risk factors. PWV × APOE-ε4 related to poorer performance on measures of lexical retrieval (β = −0.29, p = 0.01), executive function (β = −0.44, p = 0.02), and episodic memory (β = −3.07, p = 0.02). Among participants with higher aortic PWV, APOE-ε4 modified the association between central arterial stiffening and cognition, such that carriers had worse performances than noncarriers. Findings add to a growing body of evidence for APOE-vascular interactions on cognition in older adults and warrant further research into less heart-healthy cohorts where the association between PWV and cognition among older adults might be stronger.",

keywords = "Aging, Alzheimer's disease, Cardiac MRI, Mild cognitive impairment, Pulse wave velocity, Vascular risk factors",

author = "Cambronero, {Francis E.} and Dandan Liu and Neal, {Jacquelyn E.} and Moore, {Elizabeth E.} and Gifford, {Katherine A.} and Terry, {James G.} and Sangeeta Nair and Pechman, {Kimberly R.} and Osborn, {Katie E.} and Hohman, {Timothy J.} and Bell, {Susan P.} and Sweatt, {J. David} and Wang, {Thomas J.} and Beckman, {Joshua A.} and Carr, {John Jeffrey} and Jefferson, {Angela L.}",

note = "Funding Information: This research was supported by T32-MH064913 (FEC), R25-GM062459 (FEC), Alzheimer's Association IIRG-08-88733 (ALJ), R01-AG034962 (ALJ), R01-HL111516 (ALJ), R01-NS100980 (ALJ), R01-MH057014 (JDS), K24-AG046373 (ALJ), Paul B. Beeson Career Development Award in Aging K23-AG030962 (ALJ), K12-HD043483 (KAG, SPB, and TJH), Paul B. Beeson Career Development Award in Aging K23-AG045966 (KAG), Paul B. Beeson Career Development Award in Aging K23-AG048347 (SPB), K01-AG049164 (TJH), UL1-TR000445 (Vanderbilt Clinical Translational Science Award), S10-OD023680 (Vanderbilt's High-Performance Computer Cluster for Biomedical Research), R24-HL085343 (Cardiovascular Research Grid Project, JJC), and the Vanderbilt Memory & Alzheimer's Center. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = jul,

doi = "10.1016/j.neurobiolaging.2018.02.009",

language = "English (US)",

volume = "67",

pages = "120--127",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - APOE genotype modifies the association between central arterial stiffening and cognition in older adults

AU - Cambronero, Francis E.

AU - Liu, Dandan

AU - Neal, Jacquelyn E.

AU - Moore, Elizabeth E.

AU - Gifford, Katherine A.

AU - Terry, James G.

AU - Nair, Sangeeta

AU - Pechman, Kimberly R.

AU - Osborn, Katie E.

AU - Hohman, Timothy J.

AU - Bell, Susan P.

AU - Sweatt, J. David

AU - Wang, Thomas J.

AU - Beckman, Joshua A.

AU - Carr, John Jeffrey

AU - Jefferson, Angela L.

N1 - Funding Information: This research was supported by T32-MH064913 (FEC), R25-GM062459 (FEC), Alzheimer's Association IIRG-08-88733 (ALJ), R01-AG034962 (ALJ), R01-HL111516 (ALJ), R01-NS100980 (ALJ), R01-MH057014 (JDS), K24-AG046373 (ALJ), Paul B. Beeson Career Development Award in Aging K23-AG030962 (ALJ), K12-HD043483 (KAG, SPB, and TJH), Paul B. Beeson Career Development Award in Aging K23-AG045966 (KAG), Paul B. Beeson Career Development Award in Aging K23-AG048347 (SPB), K01-AG049164 (TJH), UL1-TR000445 (Vanderbilt Clinical Translational Science Award), S10-OD023680 (Vanderbilt's High-Performance Computer Cluster for Biomedical Research), R24-HL085343 (Cardiovascular Research Grid Project, JJC), and the Vanderbilt Memory & Alzheimer's Center. Publisher Copyright: © 2018 Elsevier Inc.

PY - 2018/7

Y1 - 2018/7

N2 - Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 ± 7 years, 29% APOE-ε4 carrier) and mild cognitive impairment (n = 121, 73 ± 8 years, 42% APOE-ε4 carrier) completed neuropsychological assessment and cardiac MRI to assess aortic stiffening using pulse wave velocity (PWV, m/s). Linear regression models stratified by cognitive diagnosis related aortic PWV × APOE-ε4 status to neuropsychological performances, adjusting for demographic and vascular risk factors. PWV × APOE-ε4 related to poorer performance on measures of lexical retrieval (β = −0.29, p = 0.01), executive function (β = −0.44, p = 0.02), and episodic memory (β = −3.07, p = 0.02). Among participants with higher aortic PWV, APOE-ε4 modified the association between central arterial stiffening and cognition, such that carriers had worse performances than noncarriers. Findings add to a growing body of evidence for APOE-vascular interactions on cognition in older adults and warrant further research into less heart-healthy cohorts where the association between PWV and cognition among older adults might be stronger.

AB - Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 ± 7 years, 29% APOE-ε4 carrier) and mild cognitive impairment (n = 121, 73 ± 8 years, 42% APOE-ε4 carrier) completed neuropsychological assessment and cardiac MRI to assess aortic stiffening using pulse wave velocity (PWV, m/s). Linear regression models stratified by cognitive diagnosis related aortic PWV × APOE-ε4 status to neuropsychological performances, adjusting for demographic and vascular risk factors. PWV × APOE-ε4 related to poorer performance on measures of lexical retrieval (β = −0.29, p = 0.01), executive function (β = −0.44, p = 0.02), and episodic memory (β = −3.07, p = 0.02). Among participants with higher aortic PWV, APOE-ε4 modified the association between central arterial stiffening and cognition, such that carriers had worse performances than noncarriers. Findings add to a growing body of evidence for APOE-vascular interactions on cognition in older adults and warrant further research into less heart-healthy cohorts where the association between PWV and cognition among older adults might be stronger.

KW - Aging

KW - Alzheimer's disease

KW - Cardiac MRI

KW - Mild cognitive impairment

KW - Pulse wave velocity

KW - Vascular risk factors

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DO - 10.1016/j.neurobiolaging.2018.02.009

M3 - Article

C2 - 29656011

AN - SCOPUS:85045274751

SN - 0197-4580

VL - 67

SP - 120

EP - 127

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

APOE genotype modifies the association between central arterial stiffening and cognition in older adults

Abstract

Keywords

ASJC Scopus subject areas

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