Aph-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad

Diane Levitan, Gang Yu, Peter St. George Hyslop, Caroline Goutte

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Nicastrin is a recently identified member of high-molecular weight complexes containing presenilin. The Caenorhabditis elegans homolog of nicastrin, aph-2, was shown to be required for GLP-1/Notch signaling in the early embryo. In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also display an egg-laying defect. We show that this latter defect is related to the SEL-12/presenilin egg-laying defect. We also show that aph-2 and sel-12 genetically interact and cooperate to regulate LIN-12/Notch signaling in the development of the somatic gonad. In addition, aph-2 and lin-12/Notch genetically interact. We illustrate a new role for aph-2 in facilitating lin-12 signaling in the somatic gonad, thus providing evidence that APH-2 is involved in both GLP-1/Notch- and LIN-12/Notch-mediated signaling events. Finally, we demonstrate that nicastrin can partially substitute for aph-2, suggesting a conservation of function between these proteins.

Original languageEnglish (US)
Pages (from-to)654-661
Number of pages8
JournalDevelopmental Biology
Issue number2
StatePublished - Dec 15 2001


  • APH-2
  • Alzheimer's disease
  • C. elegans
  • LIN-12
  • Nicastrin
  • Notch
  • Presenilin

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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