Anxiolytic-like effects of alverine citrate in experimental mouse models of anxiety

Deepali Gupta, Mahesh Radhakrishnan, Yeshwant Kurhe

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Anxiety disorders are widely spread psychiatric illnesses that are a cause of major concern. Despite a consistent increase in anxiolytics, the prevalence of anxiety is static; this necessitates the development of new compounds with potential activity and minimum unwanted effects. A serotonergic (5HT) system plays an important role in pathogenesis of anxiety and predominantly involves 5HT1Areceptor action in mediating anxiety-like behavior; the antagonism of 5HT1Areceptor has demonstrated to produce anxiolytic-like effects. Alverine citrate (AVC) is reported as a 5HT1Aantagonist; however, its effects on anxiety-like behavior are not investigated. Thus, the present study, by utilizing a neurobehavioral approach, examined the anxiolytic-like effects of AVC in experimental mouse models of anxiety. Mice were acutely treated with AVC (5–20 mg/kg, i.p.)/diazepam (DIA, 2 mg/kg, i.p.) and subjected to four validated anxiety models viz. elevated plus-maze (EPM), light/dark (L/D), hole-board (HB) and marble burying (MB) tests. AVC (15–20 mg/kg) and DIA significantly increased open arm activity in EPM, exploration in light chamber in L/D test, exploratory behavior in HB and reduced MB behavior in marble burying test. AVC (5 mg/kg) had no effect on all behavioral tests, while AVC (10 mg/kg) produced partial effects. It revealed anxiolytic-like effects of AVC. Furthermore, anxiolytic-like effects of AVC at higher doses (15–20 mg/kg) were more pronounced than lower doses (10 mg/kg) and were quite similar to the standard drug DIA. The present finding demonstrates, for the first time, the anxiolytic-like effects of AVC, which may be an alternative approach for management of anxiety-related disorders.

Original languageEnglish (US)
Pages (from-to)94-101
Number of pages8
JournalEuropean Journal of Pharmacology
StatePublished - 2014
Externally publishedYes


  • 5HTantagonist
  • Alverine citrate
  • Anxiolytic-like effects
  • Elevated-plus maze
  • Hole-board
  • Marble burying test

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Anxiolytic-like effects of alverine citrate in experimental mouse models of anxiety'. Together they form a unique fingerprint.

Cite this