Anxiety as a predictor of treatment outcome in children and adolescents with depression

Amy Cheung, Taryn Mayes, Anthony Levitt, Ayal Schaffer, Erin Michalak, Alex Kiss, Graham Emslie

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: The aim of this study was to examine the impact of co-morbid illnesses on treatment outcomes in depressed children and adolescents aged 7-17 who were treated with fluoxetine. Method: This data set was drawn from two large clinical trials involving children and adolescents with depression. Subjects with a diagnosis of major depressive disorder and depressive symptoms of at least moderate severity as defined by a Children's Depression Rating Score, Revised (CDRS-R) total score ≥40 and a Clinical Global Impressions-Severity (CGI-S) rating ≥4 were included. Subjects were randomized to receive fluoxetine or placebo over an 8-week period. Predictor analyses examining two primary outcomes were conducted: (1) Response based on Clinical Global Impressions-Improvement (CGI-I) score of 1 or 2, and (2) remission based on CDRS-R score of ≤28. Logistic regression models were run to assess whether anxiety disorders were a predictor of response or remission. Result: A total of 309 study participants were included. The only factor found to influence response was treatment with fluoxetine (p? =? 0.022, odds ratio [OR]? =? 2.08, 95% confidence interval [CI] 1.30, 3.31). Several factors were found to influence remission: Treatment with fluoxetine (p? <? 0.0001, OR? =? 3.17, 95% CI 1.80, 5.57), gender (p? =? 0.024, OR? =? 1.90, 95% CI 1.09, 3.30), and number of co-morbid diagnoses (p? =? 0.026, OR 0.73, 95% CI 0.55, 0.96). Conclusion: Anxiety disorders alone did not predict response or remission, but the total number of co-morbid illnesses was associated with remission in depressed children and adolescents treated with fluoxetine.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalJournal of Child and Adolescent Psychopharmacology
Issue number3
StatePublished - Jun 1 2010

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)


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