TY - JOUR
T1 - Antiplatelet therapy changes for patients with myocardial infarction with recurrent ischemic events
T2 - Insights into contemporary practice from the TRANSLATE-ACS (treatment with ADP receptor inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary syndrome) study
AU - Fanaroff, Alexander C.
AU - Kaltenbach, Lisa A.
AU - Peterson, Eric D.
AU - Akhter, Mohammed W.
AU - Effron, Mark B.
AU - Henry, Timothy D.
AU - Wang, Tracy Y.
N1 - Funding Information:
Fanaroff reports grants from the National Institutes of Health (5T32HL069749-13) and the American Heart Association (17FTF33661087); and research funding from Gilead Sciences. Peterson reports research funding from the American College of Cardiology, American Heart Association, Eli Lilly & Company, Janssen Pharmaceuticals, and Society of Thoracic Surgeons; and consulting for Merck & Co, Boehringer Ingelheim, Genentech, Janssen Pharmaceuticals, and Sanofi-Aventis. Effron reports being an employee of Eli Lilly and Company at the time of the study and a shareholder of Eli Lilly and Company (significant). Wang reports research grants to the Duke Clinical Research Institute from AstraZeneca, Boston Scientific, Daiichi Sankyo, Eli Lilly, Gilead Sciences, Glaxo Smith Kline, and Regeneron Pharmaceuticals; honorarium for educational activities from AstraZeneca; and consulting for Eli Lilly and Astra Zeneca. The remaining authors have no disclosures to report.
Publisher Copyright:
© 2018 The Authors.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Background--Guidelines recommend P2Y12 inhibitor therapy for 1 year after myocardial infarction (MI), yet little guidance is provided on antiplatelet management for patients with recurrent ischemic events during that year. We describe changes in P2Y12 inhibitor type among patients with recurrent ischemic events in the first year after MI. Methods and Results--The TRANSLATE-ACS (Treatment WithADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After AcuteCoronary Syndrome) study enrolled 12 365 patients with MI treated with percutaneous coronary intervention. We examined whether P2Y12 inhibitor choice changed among patients with recurrent MI, stent thrombosis, and/or unplanned revascularization during the first year after MI, and modeled factors associated with P2Y12 inhibitor intensification (changing clopidogrel to prasugrel or ticagrelor). In the first year after MI, 1414 patients (11%) had a total of 1740 recurrent ischemic events (771 recurrent MIs, 969 unplanned revascularizations, and 165 stent thromboses). Median time to the first recurrent ischemic event was 154 days (25th-75th percentiles, 55-287 days). Of those with recurrent ischemic events, 101 of 1092 (9.3%) occurring in clopidogrel-treated patients led to P2Y12 inhibitor intensification. Recurrent events involving stent thrombosis or MI were the strongest factors associated with P2Y12 inhibitor intensification, yet only 40% of patients with stent thrombosis and 14% of patients with recurrent MI had P2Y12 inhibitor intensification. Increasing age and longer time from the index MI were associated with lower likelihood for intensification. Conclusions--Few patients after MI with a recurrent ischemic event who were taking clopidogrel switched to a more potent P2Y12 inhibitor, even after stent thrombosis events. Specific guidance is needed for patients who have recurrent ischemic events, particularly when closely spaced.
AB - Background--Guidelines recommend P2Y12 inhibitor therapy for 1 year after myocardial infarction (MI), yet little guidance is provided on antiplatelet management for patients with recurrent ischemic events during that year. We describe changes in P2Y12 inhibitor type among patients with recurrent ischemic events in the first year after MI. Methods and Results--The TRANSLATE-ACS (Treatment WithADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After AcuteCoronary Syndrome) study enrolled 12 365 patients with MI treated with percutaneous coronary intervention. We examined whether P2Y12 inhibitor choice changed among patients with recurrent MI, stent thrombosis, and/or unplanned revascularization during the first year after MI, and modeled factors associated with P2Y12 inhibitor intensification (changing clopidogrel to prasugrel or ticagrelor). In the first year after MI, 1414 patients (11%) had a total of 1740 recurrent ischemic events (771 recurrent MIs, 969 unplanned revascularizations, and 165 stent thromboses). Median time to the first recurrent ischemic event was 154 days (25th-75th percentiles, 55-287 days). Of those with recurrent ischemic events, 101 of 1092 (9.3%) occurring in clopidogrel-treated patients led to P2Y12 inhibitor intensification. Recurrent events involving stent thrombosis or MI were the strongest factors associated with P2Y12 inhibitor intensification, yet only 40% of patients with stent thrombosis and 14% of patients with recurrent MI had P2Y12 inhibitor intensification. Increasing age and longer time from the index MI were associated with lower likelihood for intensification. Conclusions--Few patients after MI with a recurrent ischemic event who were taking clopidogrel switched to a more potent P2Y12 inhibitor, even after stent thrombosis events. Specific guidance is needed for patients who have recurrent ischemic events, particularly when closely spaced.
KW - Clopidogrel
KW - Coronary revascularization
KW - Myocardial infarction
KW - Secondary prevention
KW - Stent thrombosis
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U2 - 10.1161/JAHA.117.007982
DO - 10.1161/JAHA.117.007982
M3 - Article
C2 - 29437596
AN - SCOPUS:85042149073
SN - 2047-9980
VL - 7
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 4
M1 - e007982
ER -