Antiphospholipid antibodies in patients without systemic lupus erythematosus: Neuroradiologic findings

James M. Provenzale, E. Ralph Heinz, Thomas L. Ortel, B. Gail Macik, Linda A. Charles, Mark J. Alberts

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


PURPOSE: To study neuroradiologic findings in patients with hypercoaguability due to antiphospholipid antibodies (APAs). MATERIALS AND METHODS: Retrospective review of abnormal angiographic, computed tomographic, and magnetic resonance imaging findings was performed over a 14-month period in patients with APAs, no diagnosis of systemic lupus erythematosus, age less than 65 years, and no other cause of a hypercoaguable state. RESULTS: Fourteen patients (age range, 22-62 years) with APAs had abnormal results at neuroradiologic examination. Abnormal findings on cross-sectional imaging studies included large-artery (n = 3), lacunar (n = 5), and venous infarctions (n = 2); cortical atrophy (n = 5); white matter abnormalities (n = 3); and dural sinus thrombosis (n = 4). Abnormal angiographic findings included large-artery occlusions (n = 2), arterial narrowing that simulated vasculitis (n = 2), and transverse sinus thrombosis (n = 1). CONCLUSION: Presence of APAs should be suspected when no cause is apparent for either (a) an ischemic cerebrovascular event in young and middle-aged adults or (b) dural sinus or cerebral venous thrombosis (c) in patients with recurrent systemic arterial or venous thromboses, especially women with recurrent miscarriages.

Original languageEnglish (US)
Pages (from-to)531-537
Number of pages7
Issue number2
StatePublished - Aug 1994


  • Antibodies
  • Brain, ischemia
  • Cerebral blood vessels, thrombosis
  • Monoclonal antibodies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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