Antimicrobial management measures to limit resistance: A process-based conceptual framework

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


To curb the trend toward increasingly resistant microorganisms, we must at least ensure that antibiotics are used in accordance with the best available scientific evidence. Here we review the control and streamlining measures aimed at optimizing the use of antibiotics, placing an emphasis on their demonstrated effectiveness in the intensive care unit environment. Because of their wide variety, the measures have been organized along the process of choosing, dosing, delivering, and then adjusting the initial antibiotics according to the culture results. By clarifying the range of options available, this process-based conceptual framework assists in best adapting a creative mixture of control measures to a particular healthcare system. The framework also facilitates the overview of a proposed multidisciplinary antibiotic management program, thereby helping to secure the administrative and local provider support necessary for its implementation and continued improvement.

Original languageEnglish (US)
Pages (from-to)N121-N127
JournalCritical care medicine
Issue number4 SUPPL.
StatePublished - 2001


  • Antibiotic control
  • Antibiotic management
  • Infection control
  • Intensive care
  • Resistance
  • Review
  • Streamlining
  • Vancomycin

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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