Anticoagulation Therapy in Microsurgery: A Review

Morad Askari; Christine Fisher; Frederick G. Weniger; Sean Bidic; W. P.Andrew Lee

doi:10.1016/j.jhsa.2006.02.023

Anticoagulation Therapy in Microsurgery: A Review

Morad Askari, Christine Fisher, Frederick G. Weniger, Sean Bidic, W. P.Andrew Lee

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The advent of microsurgical tissue transfer including replantation greatly has expanded the scope of reconstructive surgery. There are few recent innovations in anticoagulation therapies for microsurgery, however, and anastomotic thrombosis remains an occasional cause of surgical failure. No consensus exists on the ideal anticoagulation protocol for microsurgery. This article reviews major pharmacologic modalities of anticoagulation, delineates the mechanism of action and study of efficacy of each agent, and compares the risks and benefits of popular anticoagulation therapies. Finally, it examines available human outcomes-based data and attempts to provide a glimpse of the future direction of microsurgical anticoagulation research.

Original language	English (US)
Pages (from-to)	836-846
Number of pages	11
Journal	Journal of Hand Surgery
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.jhsa.2006.02.023
State	Published - May 1 2006
Externally published	Yes

Keywords

Microsurgery
anticoagulation
flap
heparin
thrombosis

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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10.1016/j.jhsa.2006.02.023

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AU - Weniger, Frederick G.

AU - Bidic, Sean

AU - Lee, W. P.Andrew

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AB - The advent of microsurgical tissue transfer including replantation greatly has expanded the scope of reconstructive surgery. There are few recent innovations in anticoagulation therapies for microsurgery, however, and anastomotic thrombosis remains an occasional cause of surgical failure. No consensus exists on the ideal anticoagulation protocol for microsurgery. This article reviews major pharmacologic modalities of anticoagulation, delineates the mechanism of action and study of efficacy of each agent, and compares the risks and benefits of popular anticoagulation therapies. Finally, it examines available human outcomes-based data and attempts to provide a glimpse of the future direction of microsurgical anticoagulation research.

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KW - anticoagulation

KW - flap

KW - heparin

KW - thrombosis

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Anticoagulation Therapy in Microsurgery: A Review

Abstract

Keywords

ASJC Scopus subject areas

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