Anticoagulation Therapy in Microsurgery: A Review

Morad Askari, Christine Fisher, Frederick G. Weniger, Sean Bidic, W. P.Andrew Lee

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


The advent of microsurgical tissue transfer including replantation greatly has expanded the scope of reconstructive surgery. There are few recent innovations in anticoagulation therapies for microsurgery, however, and anastomotic thrombosis remains an occasional cause of surgical failure. No consensus exists on the ideal anticoagulation protocol for microsurgery. This article reviews major pharmacologic modalities of anticoagulation, delineates the mechanism of action and study of efficacy of each agent, and compares the risks and benefits of popular anticoagulation therapies. Finally, it examines available human outcomes-based data and attempts to provide a glimpse of the future direction of microsurgical anticoagulation research.

Original languageEnglish (US)
Pages (from-to)836-846
Number of pages11
JournalJournal of Hand Surgery
Issue number5
StatePublished - May 1 2006
Externally publishedYes


  • Microsurgery
  • anticoagulation
  • flap
  • heparin
  • thrombosis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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