Antibody-toxin hybrids: A clinical review of their use

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14 Scopus citations


Immunotoxins are protein molecules composed of monoclonal antibodies linked covalently to either peptide toxins or polypeptides related to toxins. These molecules can be used in the therapy of a number of malignant diseases including lymphoma, leukemia, and solid tumors. They can be used to prevent graft-versus-host disease or rejection in transplanted organs, such as bone marrow and pancreas. The design and development of these molecules, as well as a clinical development plan, will be discussed.

Original languageEnglish (US)
Pages (from-to)437-446
Number of pages10
JournalJournal of Biological Response Modifiers
Issue number5
StatePublished - Oct 1985


  • Immunotoxin

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Cancer Research


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