@article{e5fa152e8d20401a87d6d74add2f646d,
title = "Antibody Subclass and Glycosylation Shift Following Effective TB Treatment",
abstract = "With an estimated 25% of the global population infected with Mycobacterium tuberculosis (Mtb), tuberculosis (TB) remains a leading cause of death by infectious diseases. Humoral immunity following TB treatment is largely uncharacterized, and antibody profiling could provide insights into disease resolution. Here we focused on the distinctive TB-specific serum antibody features in active TB disease (ATB) and compared them with latent TB infection (LTBI) or treated ATB (txATB). As expected, di-galactosylated glycan structures (lacking sialic acid) found on IgG-Fc differentiated LTBI from ATB, but also discriminated txATB from ATB. Moreover, TB-specific IgG4 emerged as a novel antibody feature that correlated with active disease, elevated in ATB, but significantly diminished after therapy. These findings highlight 2 novel TB-specific antibody changes that track with the resolution of TB and may provide key insights to guide TB therapy.",
keywords = "Fc-glycosylation, IgG4, TB therapy, antibodies, tuberculosis",
author = "Grace, {Patricia S.} and Sepideh Dolatshahi and Lu, {Lenette L.} and Adam Cain and Fabrizio Palmieri and Linda Petrone and Fortune, {Sarah M.} and Ottenhoff, {Tom H.M.} and Lauffenburger, {Douglas A.} and Delia Goletti and Joosten, {Simone A.} and Galit Alter",
note = "Funding Information: This work was supported by the Ragon Institute (to GA), the SAMANA Kay MGH Research Scholar Program (to GA), NIH T32 AI007061 (to PG), and Italian Ministry of Health Ricerca corrente, Linea 4 (to DG). Funding Information: We would like to acknowledge the patients, without whom this study would not have been possible. We are also grateful to the nurses and physicians who helped with clinical aspects necessary to perform this study (National Institute for Infectious Diseases, Rome, Italy). Special thanks to Valentina Vanini for the exceptional technical support and to Gilda Cuzzi for contributing to the clinical enrolment and patients{\textquoteright} data base maintenance. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Grace, Dolatshahi, Lu, Cain, Palmieri, Petrone, Fortune, Ottenhoff, Lauffenburger, Goletti, Joosten and Alter.",
year = "2021",
month = jul,
day = "5",
doi = "10.3389/fimmu.2021.679973",
language = "English (US)",
volume = "12",
journal = "Frontiers in immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
}