Antibody response following implantation of xenogenic lenticules

D. R. Willey, E. Maguen, S. Pinhas, Steven Verity, A. B. Nesburn

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Rabbits underwent implantation of either lyophilized or fresh porcine lenticules into the central or peripheral cornea. All animals were followed for up to four months by slit-lamp examination and macrophotography to determine implant rejection. Serum antibody levels to soluble porcine cornea extract were determined by an enzyme-linked immunosorbant assay. Only those animals receiving lenticules into the peripheral cornea experienced a rejection and developed an antibody response to the porcine cornea extract. The production of antibody preceded the appearance of vascularization of the implanted lenticules. Thus, the site of lenticule implantation, not the type of tissue preparation, determined the outcome of the graft.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
Issue number1
StatePublished - 1984

ASJC Scopus subject areas

  • Ophthalmology


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