Antibiotic use in the intensive care unit: The old and the new

Philip S. Barie; Mayur Narayan; Victor M. Aquino Jose; Marc J. Shapiro

doi:10.1016/B978-0-323-69787-3.00130-1

Antibiotic use in the intensive care unit: The old and the new

Philip S. Barie, Mayur Narayan, Victor M. Aquino Jose, Marc J. Shapiro

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Antibiotics are lifesaving drugs; however, inappropriate use of these medications can lead to significant complications, especially the emergence of resistant organisms. Familiarity with their pharmacokinetics, pharmacodynamics, and volumes of distributions is of the utmost importance in their safe and effective administration. Similarly, indications for their use, proper dosing, dosages, and routes of elimination must be taken into account during their administration. This chapter covers in great detail the principles of antimicrobial therapy including prophylaxis, empiric administration of antibiotics, as well as the duration of therapy. Proper and continuous efforts to identify pathologic bacteria and the ability to differentiate colonizing bacteria is of the utmost importance.

Original language	English (US)
Title of host publication	Current Therapy of Trauma and Surgical Critical Care
Publisher	Elsevier
Pages	803-814.e1
ISBN (Electronic)	9780323697873
DOIs	https://doi.org/10.1016/B978-0-323-69787-3.00130-1
State	Published - Jan 1 2023
Externally published	Yes

Keywords

Antibiotics
bioavailability
dosages
drug resistance
duration of administration
indications
organ failure
pharmacodynamics
pharmacokinetics
prophylaxis
protein binding
routes of administration

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-69787-3.00130-1

Cite this

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Antibiotic use in the intensive care unit: The old and the new

Abstract

Keywords

ASJC Scopus subject areas

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