@article{74b042954fbc4d90b29a6ffc6f4df4bb,
title = "Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents",
abstract = "Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella.",
keywords = "Antibiotic natural product, Hunanamycin A, Riboflavin synthase, Salmonella, Structure activity relationship",
author = "Shingare, {Rahul D.} and MacMillan, {John B.} and Reddy, {D. Srinivasa}",
note = "Funding Information: We thank the CSIR, New Delhi (ORIGIN program under XII Five Year Plan, CSC0108). We thank to Incozen therapeutics for in-vitro PK studies and Intox Labs Pvt. LTD for the acute oral toxicity study. DSR thanks the DST-SERB for a J. C. Bose National Fellowship (JCB/2021/000022/SSC). R. D. S acknowledge the UGC for senior research fellowship. Funding Information: We thank the CSIR, New Delhi (ORIGIN program under XII Five Year Plan, CSC0108). We thank to Incozen therapeutics for in-vitro PK studies and Intox Labs Pvt. LTD for the acute oral toxicity study. DSR thanks the DST-SERB for a J. C. Bose National Fellowship (JCB/2021/000022/SSC). R. D. S acknowledge the UGC for senior research fellowship. Publisher Copyright: {\textcopyright} 2022",
year = "2022",
month = jun,
day = "5",
doi = "10.1016/j.ejmech.2022.114245",
language = "English (US)",
volume = "236",
journal = "CHIM.THER.",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",
}