Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors

R. Krance; H. E. Heslop; H. Mahmoud; R. Ribeiro; E. Douglass; C. Hurwitz; V. Santana; L. Kun; M. M. Horowitz; M. K. Brenner

Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors

R. Krance, H. E. Heslop, H. Mahmoud, R. Ribeiro, E. Douglass, C. Hurwitz, V. Santana, L. Kun, M. M. Horowitz, M. K. Brenner

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Six patients (five children ≤ 12 years old and one young adult) underwent allogeneic BMT (not T lymphocyte-depleted) from sex-matched HLA-identical siblings. GVHD prophylaxis consisted of methylprednisolone (30 mg/m²) and anti pan T lymphocyte ricin A chain immunotoxin (H65-RTA) (0.1 mg/kg) administered daily for 12 consecutive doses. H65 RTA was initiated at day + 5 (n = 4) or day + 2 (n = 2). All patients engrafted. Despite receiving the planned GVHD prophylaxis, all patients developed moderate to severe acute GVHD; five patients developed Grade III/IV GVHD. Four patients died 34 to 78 days post-transplant; GVHD was a contributory cause of death in each case. H65 RTA as used in this study was ineffective for the prophylaxis of acute GVHD.

Original language	English (US)
Pages (from-to)	33-36
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	11
Issue number	1
State	Published - Jan 1 1993

ASJC Scopus subject areas

Hematology
Transplantation

Cite this

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title = "Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors",

abstract = "Six patients (five children ≤ 12 years old and one young adult) underwent allogeneic BMT (not T lymphocyte-depleted) from sex-matched HLA-identical siblings. GVHD prophylaxis consisted of methylprednisolone (30 mg/m2) and anti pan T lymphocyte ricin A chain immunotoxin (H65-RTA) (0.1 mg/kg) administered daily for 12 consecutive doses. H65 RTA was initiated at day + 5 (n = 4) or day + 2 (n = 2). All patients engrafted. Despite receiving the planned GVHD prophylaxis, all patients developed moderate to severe acute GVHD; five patients developed Grade III/IV GVHD. Four patients died 34 to 78 days post-transplant; GVHD was a contributory cause of death in each case. H65 RTA as used in this study was ineffective for the prophylaxis of acute GVHD.",

author = "R. Krance and Heslop, {H. E.} and H. Mahmoud and R. Ribeiro and E. Douglass and C. Hurwitz and V. Santana and L. Kun and Horowitz, {M. M.} and Brenner, {M. K.}",

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T1 - Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors

AU - Krance, R.

AU - Heslop, H. E.

AU - Mahmoud, H.

AU - Ribeiro, R.

AU - Douglass, E.

AU - Hurwitz, C.

AU - Santana, V.

AU - Kun, L.

AU - Horowitz, M. M.

AU - Brenner, M. K.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Six patients (five children ≤ 12 years old and one young adult) underwent allogeneic BMT (not T lymphocyte-depleted) from sex-matched HLA-identical siblings. GVHD prophylaxis consisted of methylprednisolone (30 mg/m2) and anti pan T lymphocyte ricin A chain immunotoxin (H65-RTA) (0.1 mg/kg) administered daily for 12 consecutive doses. H65 RTA was initiated at day + 5 (n = 4) or day + 2 (n = 2). All patients engrafted. Despite receiving the planned GVHD prophylaxis, all patients developed moderate to severe acute GVHD; five patients developed Grade III/IV GVHD. Four patients died 34 to 78 days post-transplant; GVHD was a contributory cause of death in each case. H65 RTA as used in this study was ineffective for the prophylaxis of acute GVHD.

AB - Six patients (five children ≤ 12 years old and one young adult) underwent allogeneic BMT (not T lymphocyte-depleted) from sex-matched HLA-identical siblings. GVHD prophylaxis consisted of methylprednisolone (30 mg/m2) and anti pan T lymphocyte ricin A chain immunotoxin (H65-RTA) (0.1 mg/kg) administered daily for 12 consecutive doses. H65 RTA was initiated at day + 5 (n = 4) or day + 2 (n = 2). All patients engrafted. Despite receiving the planned GVHD prophylaxis, all patients developed moderate to severe acute GVHD; five patients developed Grade III/IV GVHD. Four patients died 34 to 78 days post-transplant; GVHD was a contributory cause of death in each case. H65 RTA as used in this study was ineffective for the prophylaxis of acute GVHD.

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JF - Bone Marrow Transplantation

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Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors

Abstract

ASJC Scopus subject areas

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